The effect of treatment with crotapotin on the evolution of experimental autoimmune neuritis induced in Lewis rats.

Abstract	Biomedical research in which venom components are being investigated for their potential as novel therapeutic agents has emerged as an interesting option. Crotapotin, which is purified from the venom of the rattlesnake Crotalus durissus terrificus, has been described as an anti-inflammatory agent that acts on the innate arm of the immune response. Here we have demonstrated that intraperitoneal administration of crotapotin significantly reduces the severity of experimental autoimmune neuritis (EAN), an experimental model for Guillain-Barré syndrome. The reduction of the severity of the disease is associated with a reduction in the mononuclear cells infiltrating the sciatic nerve and a significant decrease in the lymphocyte proliferative response to neuritogenic peptide.
Authors	Fabiano R Castro, Alessandro S Farias, Patricia L F Proença, Cristiane de La Hoz, Francesco Langone, Elaine C Oliveira, Marcos H Toyama, Sergio Marangoni, Leonilda M B Santos
Journal	Toxicon : official journal of the International Society on Toxinology (Toxicon) Vol. 49 Issue 3 Pg. 299-305 (Mar 01 2007) ISSN: 0041-0101 [Print] England
PMID	17145071 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Anti-Inflammatory Agents Myelin Proteins P2 peptide Crotoxin
Topics	Animals Anti-Inflammatory Agents (therapeutic use) Cell Proliferation (drug effects) Cells, Cultured Chromatography, High Pressure Liquid Crotalus Crotoxin (therapeutic use) Disease Models, Animal Dose-Response Relationship, Immunologic Female Guillain-Barre Syndrome Injections, Intraperitoneal Leukocytes, Mononuclear (drug effects, pathology) Lymph Nodes (drug effects, pathology) Lymphocyte Activation Myelin Proteins (immunology, pharmacology) Neuritis, Autoimmune, Experimental (immunology, pathology, prevention & control) Rats Rats, Inbred Lew Sciatic Nerve (drug effects, pathology) T-Lymphocytes (drug effects, immunology)

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