| Abstract | We report a case of generalized Wegener's granulomatosis (WG) successfully treated with high-dose methotrexate (MTX) and predonisolone (PSL). A 35 year-old men had complaints of auditory disturbance and nasal hemorrhage. Diagnosis of WG was made based on positive proteinase-3 anti-neutrophil cytoplasmic antibody (PR3-ANCA), lung nodules, and focal necrotizing glomerulonephritis revealed by renal biopsy. Treatment with cyclophosphamide (CY) and PSL for 3 months was ineffective for the lung nodules. Then, CY was changed to high dose MTX (18mg/week), and his lung lesions improved. In Japan, it is unusual to treat WG with high-dose MTX, but this treatment may be useful in CY-resistant WG. |
| Authors | Takashi Shimizu, Natsue Shimizu, Toshinori Takada, Fumitake Gejyo, Takashi Hasegawa, Eiichi Suzuki
(Affiliation: Division of Respiratory Medicine.)
|
| Journal | Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
(Nihon Kokyuki Gakkai Zasshi)
Vol. 44
Issue 11
Pg. 853-7
(Nov 2006)
ISSN: 1343-3490 Japan |
| PMID | 17144586
(Publication Type: Case Reports, English Abstract, Journal Article)
|
| Chemical References |
- Immunosuppressive Agents
- Cyclophosphamide
- Prednisolone
- Methotrexate
|
| Topics |
- Adult
- Cyclophosphamide
(pharmacology)
- Drug Administration Schedule
- Drug Resistance
- Humans
- Immunosuppressive Agents
(administration & dosage)
- Male
- Methotrexate
(administration & dosage)
- Prednisolone
(administration & dosage)
- Radiography, Thoracic
- Tomography, X-Ray Computed
- Wegener Granulomatosis
(drug therapy, radiography)
|
