| Abstract | The aim of this study was to assess the influence of trandolapril on blood pressure and ET-1 plasma activity in young patients with essential mild-to-moderate hypertension. MATERIAL AND METHODS: 19 persons with essential mild-to-moderate hypertension were enrolled into the study: the average age of this group was 17,6 +/- 1,4 years. The blood pressure and serum concentration of ET-1 in plasma were measured before enrolling and after 42 days of trandolapril (2 mg per day) therapy. The concentration of endothelin-1 was measured using RIA method. RESULTS: In the studied group, after trandolapril therapy SBP was reduced from 142.6 +/- 9,7 mmHg to 129.3 +/- 8,4 mmHg (p<0,003), DBP from 85.7 +/- 6,9 mmHg to 79.8 +/- 8,6 mmHg (p<0,01). The average serum concentration of endothelin-1 was: before therapy 9,33 +/- 1,9 fmol/ml and after therapy 8,96 +/- 2,2 fmol/ml (non-significant). CONCLUSIONS: 1. Young hypertensives treated with trandolapril (ACEI) showed significant decrease of SBP and DBP 2. 6-weeks trandolapril therapy was associated with the reduction of serum concentration of ET-1, but without statistical significance. |
| Authors | Wiesław Bryl, Danuta Pupek-Musialik
(Affiliation: Akademia Medyczna w Poznaniu, Katedra i Klinika Chorób Wewnetrznych, Zaburzeń Metabolicznych i Nadciśnienia Tetniczego. wieslawbryl at wp.pl)
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| Journal | Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
(Pol Merkur Lekarski)
Vol. 21
Issue 122
Pg. 174-5; discussion 176
(Aug 2006)
ISSN: 1426-9686 Poland |
| Vernacular Title | Wplyw terapii ACE-inhibitorem na stezenie endoteliny i wybrane parametry metaboliczne u młodych osób z nadciśnieniem tetniczym. |
| PMID | 17144105
(Publication Type: Clinical Trial, English Abstract, Journal Article)
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| Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Endothelin-1
- Indoles
- trandolapril
|
| Topics |
- Adolescent
- Adult
- Angiotensin-Converting Enzyme Inhibitors
(pharmacology, therapeutic use)
- Endothelin-1
(blood, drug effects)
- Female
- Humans
- Hypertension
(drug therapy, metabolism)
- Indoles
(pharmacology, therapeutic use)
- Male
- Treatment Outcome
|
