[The influence of ACE-inhibitor on endothelin concentration and some metabolic parameters in young hypertensives].

Abstract

UNLABELLED:

The aim of this study was to assess the influence of trandolapril on blood pressure and ET-1 plasma activity in young patients with essential mild-to-moderate hypertension.

MATERIAL AND METHODS:

19 persons with essential mild-to-moderate hypertension were enrolled into the study: the average age of this group was 17,6 +/- 1,4 years. The blood pressure and serum concentration of ET-1 in plasma were measured before enrolling and after 42 days of trandolapril (2 mg per day) therapy. The concentration of endothelin-1 was measured using RIA method.

RESULTS:

In the studied group, after trandolapril therapy SBP was reduced from 142.6 +/- 9,7 mmHg to 129.3 +/- 8,4 mmHg (p<0,003), DBP from 85.7 +/- 6,9 mmHg to 79.8 +/- 8,6 mmHg (p<0,01). The average serum concentration of endothelin-1 was: before therapy 9,33 +/- 1,9 fmol/ml and after therapy 8,96 +/- 2,2 fmol/ml (non-significant).

CONCLUSIONS:

1. Young hypertensives treated with trandolapril (ACEI) showed significant decrease of SBP and DBP 2. 6-weeks trandolapril therapy was associated with the reduction of serum concentration of ET-1, but without statistical significance.

• Authors: Wiesław Bryl, Danuta Pupek-Musialik
• Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego (Pol Merkur Lekarski) Vol. 21 Issue 122 Pg. 174-5; discussion 176 (Aug 2006) ISSN: 1426-9686 [Print] Poland
• Vernacular Title: Wplyw terapii ACE-inhibitorem na stezenie endoteliny i wybrane parametry metaboliczne u młodych osób z nadciśnieniem tetniczym.
• PMID: 17144105 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Angiotensin-Converting Enzyme Inhibitors
• Endothelin-1
• Indoles
• trandolapril

Topics

• Adolescent
• Adult
• Angiotensin-Converting Enzyme Inhibitors (pharmacology, therapeutic use)
• Endothelin-1 (blood, drug effects)
• Female
• Humans
• Hypertension (drug therapy, metabolism)
• Indoles (pharmacology, therapeutic use)
• Male
• Treatment Outcome