Abstract | OBJECTIVES: METHODS: We sequenced three genes using samples from 48 or 96 hypertensive patients, identified single nucleotide polymorphisms, and genotyped them in a population-based sample of 1818 Japanese individuals (771 hypertensive individuals and 1047 controls). RESULTS: After adjustments for age, body mass index, present illness (hyperlipidaemia, diabetes mellitus), and lifestyle (smoking, alcohol consumption), multivariate logistic regression analysis revealed that -512A>G in ACADSB was associated with hypertension in women (AA vs AG + GG: odds ratio = 0.70, 95% confidence interval = 0.53-0.94). This single nucleotide polymorphism was in tight linkage disequilibrium with -254G>A. Furthermore, -1187G>C in COMT was associated with hypertension in men (GG vs CG + CC: odds ratio = 0.69, 95% confidence interval = 0.52-0.93) and was in tight linkage disequilibrium with 186C>T. After adjustments described above, -512 A>G and -254G>A in ACADSB were associated with variations in systolic blood pressure. ACADSB was in tight linkage disequilibrium with MGC35392 across a distance of 18.3 kb. COMT was not in linkage disequilibrium with any adjacent genes. Analysis indicated that two haplotypes of COMT were significantly associated with hypertension in men. CONCLUSION: Our study suggests the possible involvement of genetic polymorphisms in ACADSB and COMT in essential hypertension in the Japanese population.
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Authors | Kei Kamide, Yoshihiro Kokubo, Jing Yang, Tetsutaro Matayoshi, Nozomu Inamoto, Shin Takiuchi, Takeshi Horio, Yoshikazu Miwa, Masayoshi Yoshii, Hitonobu Tomoike, Chihiro Tanaka, Mariko Banno, Tomohiko Okuda, Yuhei Kawano, Toshiyuki Miyata |
Journal | Journal of hypertension
(J Hypertens)
Vol. 25
Issue 1
Pg. 103-10
(Jan 2007)
ISSN: 0263-6352 [Print] England |
PMID | 17143180
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- DNA-Binding Proteins
- IKZF5 protein, human
- Transcription Factors
- Ikaros Transcription Factor
- Guanine
- Cytosine
- Acyl-CoA Dehydrogenases
- Pyridoxaminephosphate Oxidase
- Methyltransferases
- Adenine
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Topics |
- Acyl-CoA Dehydrogenases
(genetics)
- Adenine
- Aged
- Asian People
(genetics)
- Blood Pressure
(genetics)
- Cohort Studies
- Cytosine
- DNA-Binding Proteins
(genetics)
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Guanine
- Humans
- Hypertension
(ethnology, genetics, physiopathology)
- Ikaros Transcription Factor
- Japan
- Linkage Disequilibrium
- Logistic Models
- Male
- Methyltransferases
(genetics)
- Middle Aged
- Odds Ratio
- Polymorphism, Single Nucleotide
- Pyridoxaminephosphate Oxidase
(genetics)
- Risk Factors
- Sex Characteristics
- Sex Distribution
- Sex Factors
- Transcription Factors
(genetics)
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