Abstract | PURPOSE OF REVIEW: This review focuses on recent advances in the diagnosis, pathogenesis and treatment of antineutrophil cytoplasmic autoantibody-associated small-vessel vasculitis. RECENT FINDINGS: SUMMARY: Apart from its diagnostic potential, antineutrophil cytoplasmic autoantibodies, particularly myeloperoxidase-antineutrophil cytoplasmic autoantibodies, are directly involved in the pathogenesis of the associated vasculitides. New treatment modalities, supposedly more efficacious and less toxic than daily oral cyclophosphamide, are being tested in randomized controlled trials.
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Authors | Cees Gm Kallenberg |
Journal | Current opinion in rheumatology
(Curr Opin Rheumatol)
Vol. 19
Issue 1
Pg. 17-24
(Jan 2007)
ISSN: 1040-8711 [Print] United States |
PMID | 17143091
(Publication Type: Journal Article, Review)
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Chemical References |
- Antibodies, Antineutrophil Cytoplasmic
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Topics |
- Animals
- Antibodies, Antineutrophil Cytoplasmic
- Churg-Strauss Syndrome
(diagnosis, etiology, immunology, therapy)
- Granulomatosis with Polyangiitis
(diagnosis, etiology, immunology, therapy)
- Humans
- Models, Immunological
- Vasculitis
(diagnosis, etiology, immunology, therapy)
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