Effects of benidipine in a rat model for experimental angina.

Abstract

To compare the antianginal effects of 1,4-dihydropyridine-type calcium-channel blockers, we evaluated the effects of benidipine, amlodipine, nifedipine, and efonidipine on vasopressin-induced myocardial ischemia in rats, an experimental model of angina. Intravenous administration of benidipine (3 microg/kg), amlodipine (1000 microg/kg), and nifedipine (100 microg/kg) suppressed the vasopressin-induced S-wave depression, an index of myocardial ischemia. Efonidipine (100 microg/kg, i.v.) tended to inhibit the S-wave depression. At the antianginal dose of each drug, amlodipine, nifedipine, and efonidipine decreased blood pressure significantly, whereas benidipine had little effect on blood pressure at a dose of 3 microg/kg. These results indicate that benidipine, unlike the other 1,4-dihydropyridine-type calcium-channel blockers examined in this study, inhibits vasopressin-induced coronary vasospasm with fewer undesirable effects such as hypotension in rats, suggesting that benidipine may be useful in the treatment of angina pectoris.

• Authors: Jun-ichi Ikeda, Masahiro Matsubara, Kozo Yao
• Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan (Yakugaku Zasshi) Vol. 126 Issue 12 Pg. 1377-81 (Dec 2006) ISSN: 0031-6903 [Print] Japan
• PMID: 17139163 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Calcium Channel Blockers
• Dihydropyridines
• Nitrophenols
• Organophosphorus Compounds
• Amlodipine
• efonidipine
• benidipine
• Nifedipine

Topics

• Amlodipine (adverse effects, therapeutic use)
• Angina Pectoris (drug therapy)
• Animals
• Blood Pressure (drug effects)
• Calcium Channel Blockers (adverse effects, therapeutic use)
• Dihydropyridines (adverse effects, therapeutic use)
• Disease Models, Animal
• Male
• Nifedipine (adverse effects, therapeutic use)
• Nitrophenols (adverse effects, therapeutic use)
• Organophosphorus Compounds (adverse effects, therapeutic use)
• Rats
• Rats, Inbred Strains