| Abstract | OBJECTIVE: To compare the ketoprofen TDS patch with diclofenac gel in the treatment of traumatic acute pain in benign sport-related soft-tissue injuries. DESIGN: 7-14 treatment days, prospective, randomised, open study. PATIENTS: Outpatients aged 18-70 years diagnosed for painful benign sport-related soft-tissue injury (sprains, strains and contusions within the prior 48 h), randomised to either ketoprofen patch 100 mg once daily (n = 114) or diclofenac gel 2-4 g three times daily (n = 109). INTERVENTION: 7-14 days of topical non-steroidal anti-inflammatory drugs treatment to assess the pain intensity changes (daily activities and spontaneous at rest) in a daily diary (100-mm Visual Analogue Scale (VAS)). Main outcome measurement: Pain intensity (VAS). RESULTS: The ketoprofen patch was not inferior to diclofenac gel in reducing the baseline pain during daily activities (difference of -1.17 mm in favour of ketoprofen patch, 95% CI (-5.86 to 3.52), reducing to the baseline VAS 79%. Ketoprofen patch presented also a higher cure rate (64%) than diclofenac gel (46%) at day 7 (p = 0.004). Patient opinions about the treatment comfort (pharmaceutical shape, application and dosage) were also statistically higher for the ketoprofen patch (>80% of the patients rated as good or excellent the patch removal and skin adherence). CONCLUSION: Ketoprofen patches are effective and safe pain relievers for the treatment of sports injury pain with advantages compared with diclofenac gel. |
| Authors | Francisco Esparza, César Cobián, José Fernando Jiménez, Juan José García-Cota, Carlos Sánchez, Antonio Maestro, Working group for the acute pain study of SETRADE
(Affiliation: Centro Médico Juan XXIII, Murcia, Spain. fesparza at pdi.ucam.edu)
|
| Journal | British journal of sports medicine
(Br J Sports Med)
Vol. 41
Issue 3
Pg. 134-9
(Mar 2007)
ISSN: 1473-0480 England |
| PMID | 17138642
(Publication Type: Clinical Trial, Phase III, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Gels
- Diclofenac
- Ketoprofen
|
| Topics |
- Administration, Topical
- Adolescent
- Adult
- Anti-Inflammatory Agents, Non-Steroidal
(adverse effects, therapeutic use)
- Athletic Injuries
(drug therapy)
- Diclofenac
(adverse effects, therapeutic use)
- Female
- Gels
- Humans
- Ketoprofen
(adverse effects, therapeutic use)
- Male
- Middle Aged
- Pain
(drug therapy, etiology)
- Prospective Studies
- Soft Tissue Injuries
(drug therapy, etiology)
- Treatment Outcome
|
