Topical ketoprofen TDS patch versus diclofenac gel: efficacy and tolerability in benign sport related soft-tissue injuries.

Abstract

OBJECTIVE:

To compare the ketoprofen TDS patch with diclofenac gel in the treatment of traumatic acute pain in benign sport-related soft-tissue injuries.

DESIGN:

7-14 treatment days, prospective, randomised, open study.

PATIENTS:

Outpatients aged 18-70 years diagnosed for painful benign sport-related soft-tissue injury (sprains, strains and contusions within the prior 48 h), randomised to either ketoprofen patch 100 mg once daily (n = 114) or diclofenac gel 2-4 g three times daily (n = 109).

INTERVENTION:

7-14 days of topical non-steroidal anti-inflammatory drugs treatment to assess the pain intensity changes (daily activities and spontaneous at rest) in a daily diary (100-mm Visual Analogue Scale (VAS)).

MAIN OUTCOME MEASUREMENT:

Pain intensity (VAS).

RESULTS:

The ketoprofen patch was not inferior to diclofenac gel in reducing the baseline pain during daily activities (difference of -1.17 mm in favour of ketoprofen patch, 95% CI (-5.86 to 3.52), reducing to the baseline VAS 79%. Ketoprofen patch presented also a higher cure rate (64%) than diclofenac gel (46%) at day 7 (p = 0.004). Patient opinions about the treatment comfort (pharmaceutical shape, application and dosage) were also statistically higher for the ketoprofen patch (>80% of the patients rated as good or excellent the patch removal and skin adherence).

CONCLUSION:

Ketoprofen patches are effective and safe pain relievers for the treatment of sports injury pain with advantages compared with diclofenac gel.

• Authors: Francisco Esparza, César Cobián, José Fernando Jiménez, Juan José García-Cota, Carlos Sánchez, Antonio Maestro, Working group for the acute pain study of SETRADE
• Journal: British journal of sports medicine (Br J Sports Med) Vol. 41 Issue 3 Pg. 134-9 (Mar 2007) ISSN: 1473-0480 [Electronic] England
• PMID: 17138642 (Publication Type: Clinical Trial, Phase III, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Gels
• Diclofenac
• Ketoprofen

Topics

• Administration, Topical
• Adolescent
• Adult
• Anti-Inflammatory Agents, Non-Steroidal (adverse effects, therapeutic use)
• Athletic Injuries (drug therapy)
• Diclofenac (adverse effects, therapeutic use)
• Female
• Gels
• Humans
• Ketoprofen (adverse effects, therapeutic use)
• Male
• Middle Aged
• Pain (drug therapy, etiology)
• Prospective Studies
• Soft Tissue Injuries (drug therapy, etiology)
• Treatment Outcome