Abstract | BACKGROUND: METHODS: Uninephrectomized spontaneously hypertensive 12-week-old rats were treated for 36 weeks with either quinapril or a combination of doxazosin plus a low quinapril dose. Tight blood pressure control was achieved with both treatments. Renal and cardiac protection was assessed by different parameters, and cardiac apoptosis was evaluated by active caspase-3, apoptotic protein and heat shock protein levels. Untreated hypertensive and normotensive rats were included as controls. RESULTS: Both treatments showed significant heart and renal protection compared with untreated animals. Both therapeutic regimes showed similar protection in renal and cardiac pathology, coronary media fibrosis, myocardial apoptosis and cardiac index. Proteinuria and left ventricular hypertrophy regression were significantly lower in the quinapril group compared with the combined treatment group. CONCLUSIONS: Blood pressure control with a high quinapril dose provided higher organ protection than a combined therapy with a lower quinapril dose. This effect was not due to a deleterious effect of doxazosin.
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Authors | Julio Gallego-Delgado, Alberto Lazaro, Dulcenombre Gomez-Garre, Julio I Osende, Maria L Gonzalez-Rubio, Marta Herraiz, Félix Manzarbeitia, José Fortes, Arturo Fernandez-Cruz, Jesús Egido |
Journal | Journal of nephrology
(J Nephrol)
2006 Sep-Oct
Vol. 19
Issue 5
Pg. 588-98
ISSN: 1121-8428 [Print] Italy |
PMID | 17136686
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antihypertensive Agents
- Tetrahydroisoquinolines
- Doxazosin
- Quinapril
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Topics |
- Animals
- Antihypertensive Agents
(adverse effects, pharmacology)
- Apoptosis
(drug effects)
- Chronic Disease
- Disease Models, Animal
- Doxazosin
(adverse effects, pharmacology)
- Fibrosis
(chemically induced, prevention & control)
- Humans
- Hypertension
(complications, drug therapy, pathology)
- Hypertrophy, Left Ventricular
(chemically induced, prevention & control)
- Male
- Myocytes, Cardiac
(pathology)
- Quinapril
- Rats
- Rats, Inbred SHR
- Rats, Inbred WKY
- Tetrahydroisoquinolines
(adverse effects, pharmacology)
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