Abstract | OBJECTIVE: METHODS: Clinical characteristics, sex hormones and fasting- and after OGTT-glycemia and insulinemia, homeostatic model of insulin resistance (HOMA IR), and Matsuda index of insulin sensitivity were analyzed in 130 women with PCOS. Hirsutism has been evaluated through the Ferriman-Gallwey (FG) map scoring system. RESULTS: PCOS women with hirsutism (57.7% of participants) showed significant higher values of total testosterone levels (P = 0.016), free testosterone (P = 0.027), DHEA sulfate (P = 0.017), and Delta4androstenedione (P = 0.018). They had similar body mass index (BMI) (P = 0.073) and were significantly less insulin sensitive (P = 0.002) than those without hirsutism (42.3% of participants). In women with PCOS and hirsutism, there was a significant correlation between FG score and insulin-sensitivity indexes (HOMA IR, rho = 0.33, P = 0.005; Matsuda index, rho = -0.34, P = 0.003) but not with the androgen levels. Moreover, women with hirsutism showed a significantly greater insulin (P = 0.019), C-peptide (P = 0.002), and glucose (P = 0.024) areas under the curve (auc2h). CONCLUSIONS:
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Authors | Marco C Amato, Aldo Galluzzo, Simona Merlino, Antonina Mattina, Pierina Richiusa, Angela Criscimanna, Carla Giordano |
Journal | European journal of endocrinology
(Eur J Endocrinol)
Vol. 155
Issue 6
Pg. 859-65
(Dec 2006)
ISSN: 0804-4643 [Print] England |
PMID | 17132756
(Publication Type: Journal Article)
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Chemical References |
- Testosterone
- Androstenedione
- Dehydroepiandrosterone Sulfate
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Topics |
- Adolescent
- Adult
- Androstenedione
(blood)
- Dehydroepiandrosterone Sulfate
(blood)
- Diagnosis, Differential
- Female
- Hirsutism
(diagnosis, etiology, metabolism)
- Humans
- Hyperandrogenism
(complications, diagnosis, metabolism)
- Hyperinsulinism
(diagnosis, etiology, metabolism)
- Insulin Resistance
- Metabolic Syndrome
(complications, diagnosis, metabolism)
- Obesity
(diagnosis, etiology, metabolism)
- Polycystic Ovary Syndrome
(complications, diagnosis, metabolism)
- Sicily
- Testosterone
(blood)
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