Morphological study of the capsular organization around tissue expanders coated with N-carboxybutyl chitosan.

Abstract

Expanders coated with N-carboxybutyl chitosan were inserted into surgical wounds in the dorsal skin of rabbits and the formation of capsular tissue was studied by scanning electron microscopy and transmission electron microscopy. N-carboxybutyl chitosan, in the course of the capsular organization, favours and potentiates the correct proliferation and organization of the tissue, rather than sustaining reactive processes leading to scar formation. N-carboxybutyl chitosan stimulates physiologically the tissue repair process and favours angiogenesis, whilst depressing fibrogenesis to a certain extent. Applications are envisaged in the treatment of wounds and in plastic surgery.

• Authors: G Biagini, A Pugnaloni, A Damadei, A Bertani, A Belligolli, V Bicchiega, R Muzzarelli
• Journal: Biomaterials (Biomaterials) Vol. 12 Issue 3 Pg. 287-91 (Apr 1991) ISSN: 0142-9612 [Print] Netherlands
• PMID: 1713079 (Publication Type: Journal Article)

Chemical References

• Biocompatible Materials
• N-carboxybutyl chitosan
• Chitin
• Collagen
• Chitosan

Topics

• Animals
• Biocompatible Materials
• Chitin (analogs & derivatives)
• Chitosan
• Collagen (analysis)
• Cytoplasm (ultrastructure)
• Fibroblasts (ultrastructure)
• Microscopy, Electron, Scanning
• Neovascularization, Pathologic
• Organelles (ultrastructure)
• Rabbits
• Skin (blood supply)
• Tissue Expansion Devices