Pregnancy associated with lupus anticoagulant and heparin induced thrombocytopenia: management with a low molecular weight heparinoid.

Abstract

The management of pregnant patients with coagulopathies and heparin induced thrombocytopenia is difficult and poorly defined. We report the case of a patient who was treated with a low molecular weight heparinoid. The treatment was complicated by the delayed occurrence of thrombocytopenia and a thrombotic event. This is the first report of thrombocytopenia caused by heparinoid. It is possible that this complication could have been avoided by a shorter duration of treatment with heparinoid and the use of Vitamin K antagonists during the second trimester of pregnancy.

• Authors: K van Besien, R Hoffman, A Golichowski
• Journal: Thrombosis research (Thromb Res) Vol. 62 Issue 1-2 Pg. 23-9 (Apr 1991) ISSN: 0049-3848 [Print] United States
• PMID: 1712988 (Publication Type: Case Reports, Journal Article)

Chemical References

• Blood Coagulation Factors
• Glycosaminoglycans
• Heparinoids
• Lupus Coagulation Inhibitor
• Dermatan Sulfate
• Heparin
• Chondroitin Sulfates
• Heparitin Sulfate
• danaparoid

Topics

• Adult
• Blood Coagulation Disorders (complications, drug therapy, immunology)
• Blood Coagulation Factors (analysis, immunology)
• Chondroitin Sulfates
• Dermatan Sulfate
• Female
• Glycosaminoglycans (therapeutic use)
• Heparin (adverse effects)
• Heparinoids (therapeutic use)
• Heparitin Sulfate
• Humans
• Lupus Coagulation Inhibitor
• Pregnancy
• Pregnancy Complications, Hematologic (chemically induced, drug therapy, immunology)
• Thrombocytopenia (chemically induced, complications, drug therapy)