Halichondria sulfonic acid, a new HIV-1 inhibitory guanidino-sulfonic acid, and halistanol sulfate isolated from the marine sponge Halichondria rugosa Ridley & Dendy.

Abstract

A new sulfur-containing guanidino derivative, halichondria sulfonic acid (1) showing anti-HIV-1 activity, and halistanol trisulfate (2) with anti-tumor activity have been isolated from the marine sponge Halichondria rugosa Ridley & Dendy collected in the Chinese Southern Sea. The structure of 1 was elucidated by analysis of spectroscopic and crystal data.

• Authors: Y Jin, S Fotso, Z Yongtang, M Sevvana, H Laatsch, W Zhang
• Journal: Natural product research (Nat Prod Res) Vol. 20 Issue 12 Pg. 1129-35 (Oct 2006) ISSN: 1478-6419 [Print] England
• PMID: 17127667 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-HIV Agents
• Guanidines
• Halichondria sulfonic acid
• Sterols
• Sulfonic Acids
• Tetrazolium Salts
• Thiazoles
• halistanol trisulfate
• thiazolyl blue

Topics

• Animals
• Anti-HIV Agents (chemistry, isolation & purification, toxicity)
• Cell Line
• Cell Survival (drug effects)
• China
• Crystallography, X-Ray
• Enzyme-Linked Immunosorbent Assay
• Guanidines (chemistry, isolation & purification, toxicity)
• HIV-1 (drug effects)
• Inhibitory Concentration 50
• Molecular Structure
• Oceans and Seas
• Porifera (chemistry)
• Spectrophotometry, Infrared
• Spectrum Analysis
• Sterols (chemistry, isolation & purification, toxicity)
• Sulfonic Acids (chemistry, isolation & purification, toxicity)
• Tetrazolium Salts
• Thiazoles