Thyrotoxicosis and thyroid storm.

Abstract

Thyroid storm represents the extreme manifestation of thyrotoxicosis as a true endocrine emergency. Although Grave's disease is the most common underlying disorder in thyroid storm, there is usually a precipitating event or condition that transform the patient into life-threatening thyrotoxicosis. Treatment of thyroid storm involves decreasing new hormone synthesis, inhibiting the release of thyroid hormone, and blocking the peripheral effects of thyroid hormone. This multidrug, therapeutic approach uses thionamides, iodine, beta-adrenergic receptor antagonists, corticosteroids in certain circumstances, and supportive therapy. Certain conditions may warrant the use of alternative therapy with cholestyramine, lithium carbonate, or potassium perchlorate. After the critical illness of thyroid storm subsides, definitive treatment of the underlying thyrotoxicosis can be planned.

• Authors: Bindu Nayak, Kenneth Burman
• Journal: Endocrinology and metabolism clinics of North America (Endocrinol Metab Clin North Am) Vol. 35 Issue 4 Pg. 663-86, vii (Dec 2006) ISSN: 0889-8529 [Print] United States
• PMID: 17127140 (Publication Type: Journal Article, Review)

Chemical References

• Adrenergic beta-Antagonists
• Antithyroid Agents
• Triiodothyronine
• Thyroxine

Topics

• Adrenergic beta-Antagonists (therapeutic use)
• Antithyroid Agents (therapeutic use)
• Female
• Humans
• Male
• Thyroid Crisis (blood, diagnosis, drug therapy, pathology)
• Thyroxine (blood)
• Triiodothyronine (blood)