MHC class II genes in Mexican patients with idiopathic dilated cardiomyopathy.

Abstract

The purpose of the present study was to evaluate the relationship between class II major histocompatibility complex (MHC) genes (HLA-DR and HLA-DQB) and the genetic susceptibility to idiopathic dilated cardiomyopathy (IDC) in Mexican patients. The HLA-DR and DQB alleles were analyzed in 53 patients with IDC and 99 ethnically matched healthy controls using the polymerase chain reaction-sequence specific oligonucleotides (PCR-SSO) technique. IDC patients showed increased frequencies of HLA-DR4 (pC=0.02, OR=1.87), HLA-DQB1*0301 (pC=0.02, OR=1.92) and HLA-DQB1*0302 (pC=0.02, OR=1.87) when compared to healthy controls. On the other hand, IDC patients also showed decreased frequencies of HLA-DR11 allele (pC=0.03, OR=0.26) and HLA-DQB1*0201 (pC=0.04, OR=0.41). These data suggest that variation in class II HLA alleles could be a genetic factor involved in the susceptibility to IDC of the Mexican Mestizo population.

• Authors: José Manuel Rodríguez-Pérez, José Manuel Fragoso, Edith Alvarez-León, Nancy Martínez-Rodríguez, Guillermo J Gallardo, Selene Inés-Real, Julio Granados, Pedro A Reyes, Gilberto Vargas-Alarcón
• Journal: Experimental and molecular pathology (Exp Mol Pathol) Vol. 82 Issue 1 Pg. 49-52 (Feb 2007) ISSN: 0014-4800 [Print] Netherlands
• PMID: 17126830 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Cardiomyopathy, Dilated (genetics)
• Genes, MHC Class II
• Genetic Predisposition to Disease
• Humans
• Mexico
• Polymerase Chain Reaction