Propolis is a resinous hive product collected by honeybees from plants. The
propolis produced in Southeastern of Brazil is known as green
propolis because of its color. Modern herbalists recommend its use because it displays antibacterial, antifungal,
antiviral, hepatoprotective, anti-inflammatory, immunomodulatory and anti-
ulcer properties. The anti-
ulcer activity of green
propolis hydroalcoholic
crude extract was evaluated by using models of acute gastric lesions induced by
ethanol,
indomethacin and stress in rats. Moreover, the effects of extract on gastric content volume, pH and total acidity, using pylorus ligated model were evaluated. Animals pretreated with
propolis hydroalcoholic
crude extract (50, 250 and 500 mg/kg) showed a significant reduction in lesion index, total affected area and percentage of lesion in comparison with control group (p<0.05) in the
ethanol-induced
ulcer model. Green
propolis extract, at a higher dose (500 mg/kg), displayed a significant protection by reducing (p<0.05) the evaluated parameters in the gastric ulceration induced by
indomethacin. In the stress-induced
ulcer model it was observed a significant reduction (p<0.05) in those parameters in animals treated with green
propolis extract (250 and 500 mg/kg). Regarding the pylorus ligated model it was observed that green
propolis extract (250 and 500 mg/kg) displayed an anti-secretory activity, which lead to a reduction in the gastric juice volume, total acidity and pH. These findings indicate that Brazilian green
propolis displays good anti-
ulcer activity, corroborating the folk use of
propolis preparations, and contributing for its pharmacological validation.