Interferon beta-1b exacerbates multiple sclerosis with severe optic nerve and spinal cord demyelination.

Abstract	To evaluate the effect of interferon beta-1b (IFNB-1b) on multiple sclerosis (MS) with severe optic nerve and spinal cord demyelination, we examined the relationship between IFNB-1b treatment outcome and the clinical and genetic characteristics of three types of demyelinating diseases of the central nervous system, i.e., neuromyelitis optica (NMO), MS and MS with severe optic-spinal demyelination. Japanese MS frequently carried HLA DPB10501, which is associated with NMO. MS with DPB10501 showed severe optic-spinal demyelination represented by longitudinally extensive spinal cord lesion, blindness and CSF pleocytosis. IFNB-1b treatment did not succeed in these patients because of the increase of optic nerve and spinal cord relapse and other severe side effects. IFNB-1b should not be administered to demyelinating patients with genetic and clinical characteristics mimicking NMO such as HLA DPB1*0501 allele, longitudinally extensive spinal cord lesion, blindness and CSF pleocytosis even if they have symptomatic cerebral lesions as typically seen in MS. The present study strongly suggests that these patients should be diagnosed as having NMO.
Authors	Yoko Warabi, Yoh Matsumoto, Hideaki Hayashi
Journal	Journal of the neurological sciences (J Neurol Sci) Vol. 252 Issue 1 Pg. 57-61 (Jan 15 2007) ISSN: 0022-510X [Print] Netherlands
PMID	17125797 (Publication Type: Evaluation Study, Journal Article)
Chemical References	Adjuvants, Immunologic HLA-DP Antigens HLA-DP beta-Chains HLA-DPB1 antigen HLA-DR Antigens HLA-DRB1 Chains Interferon beta-1b Interferon-beta
Topics	Adjuvants, Immunologic (therapeutic use) Adult Aged Alleles Disability Evaluation Female HLA-DP Antigens (genetics) HLA-DP beta-Chains HLA-DR Antigens (genetics) HLA-DRB1 Chains Humans Interferon beta-1b Interferon-beta (therapeutic use) Male Middle Aged Multiple Sclerosis (complications, drug therapy, genetics, pathology) Neuromyelitis Optica (complications, drug therapy, genetics, pathology) Optic Nerve (pathology) Retrospective Studies Severity of Illness Index Spinal Cord (pathology) Spinal Cord Diseases (complications, drug therapy, genetics, pathology)

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