Kahalalide derivatives from the Indian sacoglossan mollusk Elysia grandifolia.

Two new cyclic depsipeptide derivatives, kahalalides R (1) and S (2), together with two known congeners, kahalalides F (3) and D (4), were isolated from the Indian sacoglossan mollusk Elysia grandifolia. The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic (1H, 13C, COSY, HMBC) and mass spectrometric (FABMS, ESIMS, MALDI-TOF/PSD) data, which also included Marfey amino acid analyses. The new derivative kahalalide R was found to exert comparable or even higher cytotoxicity than the potential drug candidate kahalalide F toward the MCF7 human mammary carcinoma cell line.
AuthorsMohamed Ashour, RuAngelie Edrada, Rainer Ebel, Victor Wray, Wim Wätjen, K Padmakumar, Werner E G Müller, Wen Han Lin, Peter Proksch
JournalJournal of natural products (J Nat Prod) Vol. 69 Issue 11 Pg. 1547-53 (Nov 2006) ISSN: 0163-3864 [Print] United States
PMID17125219 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Depsipeptides
  • kahalalide R
  • kahalalide S
  • kahalalide F
  • Animals
  • Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
  • Cell Line, Tumor
  • Depsipeptides (chemistry, isolation & purification, pharmacology)
  • Drug Screening Assays, Antitumor
  • Female
  • Humans
  • Indian Ocean
  • Mammary Neoplasms, Animal
  • Molecular Structure
  • Mollusca (chemistry)
  • Nuclear Magnetic Resonance, Biomolecular

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