Efficacy of a skin-protection powder for use as a dressing for intractable ulcers.

Abstract

OBJECTIVE:

Stomahesive skin-protection powder has been reported to be useful as a skin-care and skin-barrier product for the management of stomas. This study aimed to evaluate its efficacy, in terms of wound healing, moisture retention and pain management, as an alternative to conventional dressing materials. Both clinical and animal studies were undertaken.

METHOD:

The efficacy of the Stomahesive powder was tested by measuring the thickness of granulation tissue formed in a total skin defect in a db/db mouse model. We then compared the healing process using either the skin-protection powder or a conventional film dressing material. In the clinical study 17 patients with various intractable ulcers were treated with Stomahesive powder, and healing was evaluated.

RESULTS:

In the mouse model, granulation tissue in the wounds treated with the powder was 2.86 times thicker than that of the wounds treated with the film dressing. In the clinical study, 16 out of 17 wounds healed completely.

CONCLUSION:

The Stomahesive powder could be an effective treatment modality for contact ulceration, superficial ulcers with complex contours and morphology, and superficial ulcers contaminated by liquid faeces or vaginal discharge that have not responded to conventional dressings.

DECLARATION OF INTEREST:

None.

• Authors: N Ohura, T Kurita, A Takushima, M Shibata, K Harii
• Journal: Journal of wound care (J Wound Care) Vol. 15 Issue 10 Pg. 471-2, 474-6 (Nov 2006) ISSN: 0969-0700 [Print] England
• PMID: 17124823 (Publication Type: Case Reports, Clinical Trial, Comparative Study, Journal Article)

Chemical References

• Drug Combinations
• Polyenes
• Powders
• stomadhesive
• Pectins
• Gelatin
• Carboxymethylcellulose Sodium

Topics

• Administration, Cutaneous
• Aged
• Aged, 80 and over
• Animals
• Carboxymethylcellulose Sodium (pharmacology, therapeutic use)
• Disease Models, Animal
• Drug Combinations
• Drug Evaluation
• Female
• Gelatin (pharmacology, therapeutic use)
• Granulation Tissue (drug effects)
• Humans
• Male
• Mice
• Mice, Inbred Strains
• Middle Aged
• Occlusive Dressings (standards)
• Pectins (pharmacology, therapeutic use)
• Polyenes (pharmacology, therapeutic use)
• Powders
• Skin Care
• Skin Ulcer (etiology, pathology, therapy)
• Statistics, Nonparametric
• Wound Healing