| Abstract | BACKGROUND/AIMS: The angiotensin I-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism has been extensively examined for the association with immunoglobulin A (IgA) nephropathy (IgAN), however, conflicting results have occurred. We performed a meta-analysis to evaluate the association of ACE I/D polymorphism with IgAN in different ethnic groups. METHODS: 11 studies testing the association between ACE I/D polymorphism and IgAN susceptibility, and 9 studies testing the association of ACE I/D with IgAN progression were used in this analysis. The overall odds ratio (OR) was estimated by a fixed or random effect model. RESULTS: The overall OR for the risk of susceptibility and progression of IgAN in Asians for the DD genotype is 2.37 (95% CI 1.04-5.41) and 1.75 (95% CI 1.24-2.56). The overall OR for the D allele in Asians also showed a similar magnitude, though without statistical significance (p = 0.09, p = 0.13, respectively). In Caucasians, both the DD genotype and D allele were associated with IgAN progression (OR 1.90, 1.61, respectively), but not IgAN susceptibility (p = 0.30, p = 0.41, respectively). CONCLUSION: Our findings support the notion that ACE I/D polymorphism is associated with IgAN. Meanwhile, the role of ACE I/D polymorphism in Asians is different from that of Caucasians. |
| Authors | Du Yong, Wu Qing Qing, Liang Hua, Jia Jing Kan, Chen Jia Xi, Qin Qiao Jin, Shen Han Chao
(Affiliation: Department of Nephrology, 2nd Affiliated Hospital, School of Medicine, Zhe Jiang University, Hangzhou, PR China. duyong717 at hotmail.com)
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| Journal | American journal of nephrology
(Am J Nephrol)
Vol. 26
Issue 5
Pg. 511-8
( 2006)
ISSN: 0250-8095 Switzerland |
| PMID | 17124384
(Publication Type: Comparative Study, Journal Article, Meta-Analysis, Validation Studies)
|
| Copyright | Copyright (c) 2006 S. Karger AG, Basel. |
| Chemical References |
- DNA Transposable Elements
- Peptidyl-Dipeptidase A
|
| Topics |
- Adult
- Asian Continental Ancestry Group
- DNA Transposable Elements
(genetics)
- European Continental Ancestry Group
- Gene Deletion
- Genetic Predisposition to Disease
(epidemiology)
- Glomerulonephritis, IGA
(enzymology, epidemiology, genetics)
- Humans
- Mutagenesis, Insertional
- Peptidyl-Dipeptidase A
(genetics)
- Polymorphism, Genetic
- Prognosis
|
