Abstract | INTRODUCTION: METHODS: Infusion with levosimendan (0.2 microg/kg/min following a bolus of 24 microg/kg) or saline was initiated 30 min prior to ischemia in anaesthetized pigs (n = 10 in both groups). Balloon occlusion of the left anterior descending coronary artery for 45 min was followed by 2 1/2 h of reperfusion. Hemodynamics were monitored with a Swan-Ganz catheter and a left ventricular pressure micromanometer. Left ventricular systolic and diastolic function was estimated by dP/dt(max) and tau, respectively. Myocardial area at risk (AAR) and IS were assessed in vivo by myocardial perfusion imaging (MPI) and ex vivo by histopathology ( fluorescein staining for AAR, tetrazolium staining for IS). RESULTS: Prior to ischemia, levosimendan improved left ventricular systolic and diastolic function with coincident preload and afterload reduction. Cardiac output increased by 10 +/- 4% (p = 0.04), dP/dt(max) by 15 +/- 5% (p = 0.01). Pulmonary capillary wedge pressure decreased by 18 +/- 3% (p = 0.04), tau by 11 +/- 2% (p = 0.001), and mean arterial pressure by 11 +/- 2% (p < 0.001). A similar trend was observed during ischemia-reperfusion. The ratio of IS/AAR was not reduced by levosimendan compared to saline as evaluated by histopathology (76 +/- 4% vs. 64 +/- 7%, p = 0.12) and by MPI (94 +/- 2% vs. 87 +/- 5%, p = 0.14). CONCLUSION:
Levosimendan improves hemodynamics but does not reduce IS in an ischemia-reperfusion model without coronary collaterals.
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Authors | Martin Busk, Michael Maeng, Jens Kristensen, Jette Scheby Berg, Ulrik Markus Mortensen, Torsten Toftegaard Nielsen, Jens Erik Nielsen-Kudsk |
Journal | Cardiovascular drugs and therapy
(Cardiovasc Drugs Ther)
Vol. 20
Issue 5
Pg. 335-42
(Oct 2006)
ISSN: 0920-3206 [Print] United States |
PMID | 17122904
(Publication Type: Journal Article)
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Chemical References |
- Cardiotonic Agents
- Hydrazones
- Pyridazines
- Vasodilator Agents
- Simendan
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Topics |
- Animals
- Blood Pressure
(drug effects)
- Cardiac Output
(drug effects)
- Cardiotonic Agents
(pharmacology)
- Female
- Heart Ventricles
(drug effects)
- Hydrazones
(pharmacology)
- Myocardial Infarction
(drug therapy, pathology)
- Myocardial Reperfusion
- Pyridazines
(pharmacology)
- Simendan
- Swine
- Vasodilator Agents
(pharmacology)
- Ventricular Function
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