Abstract | OBJECTIVE: DESIGN: We performed a prospective, single-blinded, placebo-controlled, randomised trial of 6 months duration with 2 parallel groups. PATIENTS: Twenty-five subjects with a history of differentiated thyroid carcinoma with > 10 years TSH-suppressive therapy with l-thyroxine completed the study. l-thyroxine dose was replaced by study medication containing l-thyroxine or l-thyroxine plus placebo. Medication was titrated to establish continuation of TSH suppression (low-TSH group, 13 patients) and euthyroidism (euthyroidism group, 12 patients). MEASUREMENTS: We evaluated glucose metabolism by glucose tolerance test and HOMA (IR) and lipid metabolism by lipid profile. In addition, we measured plasma concentrations of glucoregulatory hormones. RESULTS: At baseline, glucose tolerance, HOMA (IR), lipid profile and plasma concentrations of glucoregulatory hormones were within the normal range. No significant differences between the low TSH and euthyroidism group were observed. After 6 months, neither glucose nor lipid metabolism in the low TSH group were different from baseline values. CONCLUSION: In summary, glucose and lipid metabolism in patients with DTC and long-term subclinical hyperthyroidism in general are not affected. Restoration of euthyroidism in general does not affect glucose and lipid metabolism.
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Authors | K A Heemstra, J W A Smit, C F A Eustatia-Rutten, A C Heijboer, M Frölich, J A Romijn, E P M Corssmit |
Journal | Clinical endocrinology
(Clin Endocrinol (Oxf))
Vol. 65
Issue 6
Pg. 737-44
(Dec 2006)
ISSN: 0300-0664 [Print] England |
PMID | 17121524
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Insulin
- Lipids
- Thyrotropin
- Thyroxine
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Topics |
- Adult
- Carcinoma
(blood, drug therapy, surgery)
- Female
- Glucose Intolerance
- Humans
- Hyperthyroidism
(blood)
- Insulin
(blood)
- Lipids
(blood)
- Male
- Middle Aged
- Prospective Studies
- Single-Blind Method
- Thyroid Neoplasms
(blood, drug therapy, surgery)
- Thyroidectomy
- Thyrotropin
(blood)
- Thyroxine
(blood, therapeutic use)
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