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[Clinical effect of shenbing mistura combined with glucocorticoid on recurrent nephrotic syndrome in children and levels of interleukin-6 and tumor necrosis factor-alpha in blood and urine].

AbstractOBJECTIVE:
To study the effect of Shenbing Mistura (SM) combined with glucocorticoid on recurrent nephrotic syndrome (RNS) in children and levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in blood and urine.
METHODS:
The treatment group was treated with SM plus glucocorticoid, the control group with glucocorticoid alone, and a healthy control group was adopted, 30 cases in each group. The clinical effect and recurrence rate were observed, and levels of IL-6 and TNF-alpha in blood and urine were determined before treatment and at the 4th, 8th, 12th week after treatment.
RESULTS:
Significant difference of IL-6 and TNF-alpha levels in blood and urine was found in either the pre- and post- treatment auto-control of both the treatment group and control group, or in the inter-group comparison of them (P < 0.01); clinical effect also showed remarkable difference between the two groups (P < 0.01). Furthermore, the recurrence rate of the treatment group was lower than that of the control group showed by a 18-month follow-up (P < 0.01).
CONCLUSION:
SM combined with glucocorticoid could significantly reduce the recurrence rate and elevate the clinical effect in children with RNS, it could also lower the levels of IL-6 and TNF-alpha in patients' blood and urine.
AuthorsGuo-hau Hu, Xi-qiang Dang, Jing-he Wang
JournalZhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 26 Issue 10 Pg. 892-5 (Oct 2006) ISSN: 1003-5370 [Print] China
PMID17121039 (Publication Type: Clinical Trial, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Drugs, Chinese Herbal
  • Glucocorticoids
  • Interleukin-6
  • Tumor Necrosis Factor-alpha
  • shenbing mistura
  • Prednisone
Topics
  • Adult
  • Child
  • Child, Preschool
  • Drug Therapy, Combination
  • Drugs, Chinese Herbal (therapeutic use)
  • Female
  • Follow-Up Studies
  • Glucocorticoids (therapeutic use)
  • Humans
  • Interleukin-6 (analysis, blood, urine)
  • Male
  • Nephrotic Syndrome (drug therapy, pathology)
  • Phytotherapy
  • Prednisone (therapeutic use)
  • Recurrence
  • Treatment Outcome
  • Tumor Necrosis Factor-alpha (analysis, blood, urine)

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