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Efficacy of ivermectin treatment of cutaneous gnathostomiasis evaluated by placebo-controlled trial.

Abstract
Previous studies have revealed that ivermectin treatment for gnathostomiasis can reduce parasitic loads in animals and make recurrent subcutaneous swelling subside in 76% of patients. Our study aimed to evaluate the efficacy of ivermectin for cutaneous gnathostomiasis treatment in a placebo-controlled trial. This study was a prospective randomized placebo-controlled study performed at The Bangkok Hospital for Tropical Diseases, Mahidol University, Thailand. Thirty patients with a serologically confirmed diagnosis of cutaneous gnathostomiasis were enrolled. Seventeen patients in the ivermectin treated group received a single dose of 12 mg ivermectin (200 microg/kg bodyweight), while 13 patients in the control group received a single dose of 40 mg of vitamin B1. The follow-up period was 1 year. Of the 17 patients, 7 (41.2%) responded to ivermectin, while no patient responded to placebo. The mean (95% Cl) time to the first recurrence of subcutaneous swelling with ivermectin and in the placebo groups were 257 (184-331) and 146 (42-250) days, respectively, (p=0.102). Although this study revealed no significant difference in the mean time to first recurrence of swelling between the ivermectin and placebo groups, there was a trend towards ivermectin efficacy against gnathostomiasis in previous animal and human studies. Further studies with different doses of ivermectin and larger sample sizes, and close monitoring for ivermectin tolerability and treatment response are necessary to confirm an efficacy of ivermectin.
AuthorsValai Bussaratid, Varunee Desakorn, Srivicha Krudsood, Udomsak Silachamroon, Sornchai Looareesuwan
JournalThe Southeast Asian journal of tropical medicine and public health (Southeast Asian J Trop Med Public Health) Vol. 37 Issue 3 Pg. 433-40 (May 2006) ISSN: 0125-1562 [Print] Thailand
PMID17120960 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References
  • Antiparasitic Agents
  • Ivermectin
Topics
  • Adult
  • Animals
  • Antiparasitic Agents (adverse effects, therapeutic use)
  • Female
  • Gnathostoma
  • Humans
  • Ivermectin (adverse effects, therapeutic use)
  • Male
  • Middle Aged
  • Spirurida Infections (drug therapy)
  • Thailand

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