Kamikihi-to, a Kampo medicine, ameliorates impairment of spatial memory in rats.

Abstract

The present study investigated the effects of Kamikihi-to (KKT), a Kampo medicine, on impairment of spatial memory in rats using an eight-arm radial maze task. Scopolamine (0.5 mg/kg, i.p.), a non-selective muscarinic receptor antagonist, and Delta(9)-tetrahydrocannabinol (THC; 6 mg/kg, i.p.), a principal psychoactive component of marihuana, each markedly impaired the spatial memory. KKT (1 and 3 mg/kg, p.o.) significantly improved the scopolamine-induced impairment of spatial memory. KKT (30 mg/kg, p.o.) also improved significantly the THC-induced impairment of spatial memory. Moreover, KKT (3 and 30 mg/kg, p.o.) enhanced tremors induced by oxotremorine, a muscarinic M(1) receptor agonist. Taken together these findings suggest that KKT is a useful drug for treating memory deficits.

• Authors: Nobuaki Egashira, Naomi Manome, Kouji Kurauchi, Yoshiaki Matsumoto, Katsunori Iwasaki, Kenichi Mishima, Yukihiro Shoyama, Michihiro Fujiwara
• Journal: Phytotherapy research : PTR (Phytother Res) Vol. 21 Issue 2 Pg. 126-9 (Feb 2007) ISSN: 0951-418X [Print] England
• PMID: 17117451 (Publication Type: Journal Article)
• Copyright: Copyright (c) 2006 John Wiley & Sons, Ltd.

Chemical References

• Drugs, Chinese Herbal
• kamikihi-to
• Oxotremorine
• Dronabinol
• Scopolamine

Topics

• Animals
• Dronabinol (pharmacology)
• Drugs, Chinese Herbal (pharmacology, therapeutic use)
• Male
• Maze Learning (drug effects)
• Medicine, Kampo
• Memory (drug effects)
• Memory Disorders (chemically induced, drug therapy)
• Mice
• Mice, Inbred Strains
• Oxotremorine (pharmacology)
• Rats
• Rats, Wistar
• Scopolamine (pharmacology)
• Tremor (chemically induced)