Abstract | OBJECTIVE: Dietary supplementation with fish oil-derived n-3 fatty acids reduces mortality in patients with myocardial infarction, but may have adverse effects in angina patients. The underlying electrophysiologic mechanisms are poorly understood. We studied the arrhythmias and the electrophysiologic changes during regional ischemia in hearts from pigs fed a diet rich in fish oil. METHODS: Pigs received diets rich in fish oil, in sunflower oil, or a control diet for 8 weeks. Hearts were isolated and perfused. Ischemia was created by occluding the left anterior descending artery. Diastolic stimulation threshold, refractory period, conduction velocity, activation recovery intervals and the maximum downstroke velocity of 176 electrograms were measured in the ischemic zone. Spontaneous arrhythmias during 75 min of regional ischemia were counted. RESULTS: CONCLUSIONS: A diet rich in fish oil results in proarrhythmia compared to a control diet during regional ischemia in pigs. Myocardial excitability is reduced in the fish oil and sunflower oil group during the early phase of arrhythmogenesis. In the late phase of arrhythmogenesis, excitability is more reduced in the control group than in the fish oil and sunflower oil group.
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Authors | Ruben Coronel, Francien J G Wilms-Schopman, Hester M Den Ruijter, Charly N Belterman, Cees A Schumacher, Tobias Opthof, Robert Hovenier, Arnoldina G Lemmens, Antonius H M Terpstra, Martijn B Katan, Peter Zock |
Journal | Cardiovascular research
(Cardiovasc Res)
Vol. 73
Issue 2
Pg. 386-94
(Jan 15 2007)
ISSN: 0008-6363 [Print] England |
PMID | 17116294
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Fatty Acids, Omega-3
- Plant Oils
- Sunflower Oil
- Docosahexaenoic Acids
- Eicosapentaenoic Acid
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Topics |
- Animals
- Arrhythmias, Cardiac
(chemically induced, physiopathology)
- Dietary Supplements
- Docosahexaenoic Acids
(analysis, blood)
- Eicosapentaenoic Acid
(analysis, blood)
- Electrocardiography
- Fatty Acids, Omega-3
(administration & dosage)
- Heart
(physiopathology)
- Male
- Myocardial Ischemia
(metabolism, physiopathology)
- Perfusion
- Plant Oils
(administration & dosage)
- Sunflower Oil
- Swine
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