Wilson's disease associated with delusional disorder.

Wilson's disease (WD), or hepatolenticular degeneration, is a genetic neurodegenerative disorder of copper metabolism. It is an uncommon medical condition that produces psychiatric symptoms during the early phase in approximately 50% of patients. Reported herein is a case of WD in a young man presenting persistent delusional disorder of organic etiology, which resolved entirely after 4 months of combined pharmacotherapy. The present case demonstrates the importance of considering the occurrence of psychotic symptoms in WD patients given that psychiatric manifestations in WD are known to be uncommon as well as inhomogeneous. It also supports the hypothesis that psychopathologic features in WD have an organic foundation.
AuthorsHubert Michał Wichowicz, Wiesław Jerzy Cubała, Jarosław Sławek
JournalPsychiatry and clinical neurosciences (Psychiatry Clin Neurosci) Vol. 60 Issue 6 Pg. 758-60 (Dec 2006) ISSN: 1323-1316 [Print] Australia
PMID17109711 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antipsychotic Agents
  • Benzodiazepines
  • olanzapine
  • Copper
  • Adult
  • Antipsychotic Agents (therapeutic use)
  • Behavior
  • Benzodiazepines (therapeutic use)
  • Cerebrovascular Circulation
  • Copper (blood)
  • Female
  • Hepatolenticular Degeneration (drug therapy, psychology, therapy)
  • Humans
  • Magnetic Resonance Imaging
  • Neuropsychological Tests
  • Psychiatric Status Rating Scales
  • Schizophrenia, Paranoid (drug therapy, psychology, therapy)
  • Tomography, Emission-Computed, Single-Photon

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