HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study.

AbstractOBJECTIVES:
Fibromyalgia (FMS) and chronic fatigue syndrome (CFS) are debilitating syndromes that are often associated with impaired cellular energy metabolism. As D-ribose has been shown to increase cellular energy synthesis in heart and skeletal muscle, this open-label uncontrolled pilot study was done to evaluate if D-ribose could improve symptoms in fibromyalgia and/or chronic fatigue syndrome patients.
DESIGN:
Forty-one (41) patients with a diagnosis of FMS and/or CFS were given D-ribose, a naturally occurring pentose carbohydrate, at a dose of 5 g t.i.d. for a total of 280 g. All patients completed questionnaires containing discrete visual analog scales and a global assessment pre- and post-D-ribose administration.
RESULTS:
D-ribose, which was well-tolerated, resulted in a significant improvement in all five visual analog scale (VAS) categories: energy; sleep; mental clarity; pain intensity; and well-being, as well as an improvement in patients' global assessment. Approximately 66% of patients experienced significant improvement while on D-ribose, with an average increase in energy on the VAS of 45% and an average improvement in overall well-being of 30% (p < 0.0001).
CONCLUSIONS:
D-ribose significantly reduced clinical symptoms in patients suffering from fibromyalgia and chronic fatigue syndrome.
AuthorsJacob E Teitelbaum, Clarence Johnson, John St Cyr
JournalJournal of alternative and complementary medicine (New York, N.Y.) (J Altern Complement Med) Vol. 12 Issue 9 Pg. 857-62 (Nov 2006) ISSN: 1075-5535 [Print] United States
PMID17109576 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Ribose
Topics
  • Activities of Daily Living
  • Adult
  • Dose-Response Relationship, Drug
  • Fatigue Syndrome, Chronic (drug therapy)
  • Female
  • Fibromyalgia (drug therapy)
  • Humans
  • Middle Aged
  • Pain Measurement (methods)
  • Patient Satisfaction (statistics & numerical data)
  • Pilot Projects
  • Quality of Life
  • Ribose
  • Surveys and Questionnaires
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: