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Early relapse of JAK2 V617F-positive chronic neutrophilic leukemia with central nervous system infiltration after unrelated bone marrow transplantation.

Abstract
Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative disorder characterized by a proliferation mainly of mature neutrophils. The prognosis is generally poor and an optimal therapeutic strategy remains to be determined. Allogeneic hematopoietic stem cell transplantation (HSCT) is expected to be the only curative therapy so far. We report a 46-year-old male with progressive CNL who underwent bone marrow transplantation from an HLA-matched unrelated donor. After engraftment was achieved on day 35, relapse of CNL was confirmed on day 50. The progression of CNL was very rapid afterward and infiltration to the central nervous system was observed. The Janus Kinase 2 (JAK2) V617F homozygous mutation was detected from the peripheral blood or bone marrow samples throughout the clinical course. From comparison with reports of successful HSCT for CNL in the literature, it was inferred that HSCT should be performed in a stable status before progression. Furthermore, JAK2 V617F-positive CNL may contain an aggressive disease entity in contrast to previous reports. Accumulation of experiences is required to establish a definite role of HSCT in the treatment of CNL and a prognostic significance of JAK2 mutation in CNL.
AuthorsShinichi Kako, Yoshinobu Kanda, Tomohiko Sato, Susumu Goyama, Naohiro Noda, Eriko Shoda, Kumi Oshima, Morihiro Inoue, Koji Izutsu, Takuro Watanabe, Toru Motokura, Shigeru Chiba, Masashi Fukayama, Mineo Kurokawa
JournalAmerican journal of hematology (Am J Hematol) Vol. 82 Issue 5 Pg. 386-90 (May 2007) ISSN: 0361-8609 [Print] United States
PMID17109389 (Publication Type: Case Reports, Journal Article)
Copyright(c) 2006 Wiley-Liss, Inc.
Chemical References
  • Antineoplastic Agents, Alkylating
  • Arabinonucleotides
  • Neoplasm Proteins
  • 1-arabinofuranosylcytosine-5'-stearylphosphate
  • JAK2 protein, human
  • Janus Kinase 2
  • Cytidine Monophosphate
  • Hydroxyurea
Topics
  • Antineoplastic Agents, Alkylating (administration & dosage, therapeutic use)
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Arabinonucleotides (administration & dosage)
  • Bone Marrow Transplantation
  • Brain (pathology)
  • Chromosome Inversion
  • Chromosomes, Human, Pair 9 (ultrastructure)
  • Combined Modality Therapy
  • Cytidine Monophosphate (administration & dosage, analogs & derivatives)
  • Dysarthria (etiology)
  • Fatal Outcome
  • Humans
  • Hydroxyurea (administration & dosage, therapeutic use)
  • Hyperesthesia (etiology)
  • Janus Kinase 2 (genetics)
  • Leukemia, Neutrophilic, Chronic (drug therapy, enzymology, genetics, pathology, surgery)
  • Leukemic Infiltration
  • Male
  • Middle Aged
  • Neoplasm Proteins (genetics)
  • Recurrence
  • Transplantation, Homologous

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