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Healing slack skin.

Abstract
A non-lethal, murine knockout of fibulin-5 with features of autosomal recessive cutis laxa and marked defects in elastic fiber formation amplifies previous observations on the minimal role of the elastic component in acute, cutaneous wound healing. More demanding wound models or long-term studies may yet reveal how fibulin-5 and elastin impact the quality of repair.
AuthorsJeffrey M Davidson, Mariagabriella Giro
JournalThe Journal of investigative dermatology (J Invest Dermatol) Vol. 126 Issue 12 Pg. 2563-4 (Dec 2006) ISSN: 1523-1747 [Electronic] United States
PMID17108902 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S., Review)
Chemical References
  • Extracellular Matrix Proteins
  • Fbln5 protein, mouse
  • Recombinant Proteins
Topics
  • Animals
  • Cutis Laxa (genetics, physiopathology)
  • Elastic Tissue (physiopathology)
  • Extracellular Matrix Proteins (genetics)
  • Genes, Recessive
  • Mice
  • Mice, Knockout
  • Recombinant Proteins (genetics)
  • Wound Healing

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