Effect of anti-androgen (TZP-4238) on steroid-induced canine prostatic hyperplasia. Light and electron microscopic investigations.

Abstract

The effect of a synthetic steroidal anti-androgen, TZP-4238, on steroid-induced canine prostatic hyperplasia was studied by light and electron microscopy. Male beagle dogs (1-2 years old) were divided into four experimental groups. Group 1 consisted of intact controls. The other animals were castrated. The castrated animals were treated for 25 weeks with 1) 5 alpha-androstane-3 alpha, 17 beta-diol (A-diol) plus 17 beta-estradiol (E2) (Group 2), 2) A-diol plus E2 + TZP-4238 0.5 mg/kg (Group 3) and 3) A-diol plus E2 + chlormadinone acetate (CMA) 2.5 mg/kg (Group 4). TZP-4238 and CMA were administered orally for 21 weeks after 4 weeks treatment with A-diol plus E2. In group 2, glandular hyperplasia of the prostate was clearly noted. In contrast, combined treatment with TZP-4238 (Group 3) or CMA (Group 4) produced marked atrophy of the glandular epithelium. Loss of secretory and metabolic activities was confirmed by ultrastructural investigations. Our data indicate that TZP-4238 is a potent anti-androgen for the prevention of canine prostatic hyperplasia in the steroid-induced benign prostatic hyperplasia (BPH) model.

• Authors: M Murakoshi, R Inada, M Makino, M Suzuki, M Mieda, S Honma, H Yamanaka
• Journal: Acta pathologica japonica (Acta Pathol Jpn) Vol. 40 Issue 12 Pg. 871-9 (Dec 1990) ISSN: 0001-6632 [Print] Australia
• PMID: 1710865 (Publication Type: Journal Article)

Chemical References

• Androgen Antagonists
• Chlormadinone Acetate
• Androstane-3,17-diol
• Estradiol
• osaterone acetate

Topics

• Administration, Oral
• Androgen Antagonists (pharmacology)
• Androstane-3,17-diol
• Animals
• Chlormadinone Acetate (analogs & derivatives, pharmacology)
• Dogs
• Estradiol
• Male
• Microscopy, Electron
• Orchiectomy
• Organ Size
• Prostatic Hyperplasia (chemically induced, pathology, prevention & control)