Abstract | OBJECTIVE: METHODS: RESULTS: CONCLUSIONS:
Oral administration of itraconazole OS displayed therapeutic efficacy against murine oral and oesophageal candidiasis superior to that achieved by intragastric administration. This can be explained by there being higher concentrations of itraconazole in tongues or oesophagus tissues after administration of the suspension by the oral route.
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Authors | Hiroko Ishibashi, Katsuhisa Uchida, Yayoi Nishiyama, Hideyo Yamaguchi, Shigeru Abe |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 59
Issue 2
Pg. 317-20
(Feb 2007)
ISSN: 0305-7453 [Print] England |
PMID | 17107970
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antifungal Agents
- Solutions
- Itraconazole
|
Topics |
- Administration, Oral
- Animals
- Antifungal Agents
(administration & dosage, pharmacokinetics, therapeutic use)
- Candida albicans
(drug effects, growth & development)
- Candidiasis
(drug therapy, microbiology)
- Candidiasis, Oral
(drug therapy, microbiology)
- Esophagitis
(drug therapy, microbiology)
- Female
- Gastric Mucosa
(metabolism)
- Itraconazole
(administration & dosage, pharmacokinetics, therapeutic use)
- Mice
- Mice, Inbred ICR
- Solutions
- Stomach
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