The use of oxygen in Fournier's gangrene.

Abstract

Fournier's gangrene is an aggressive form of necrotizing fasciitis of the perineal, perianal or genital regions, usually caused by a polymicrobial infection that includes virulent organisms. Over the last decades, we have treated 9 patients suffering from Fournier's gangrene using systemic chemotherapy with broad-spectrum antibiotics, and with extensive, sometimes serial surgical debridement. Recently in one case, in addition to treatment, we used locally 100% oxygen in daily doses with promising results in healing wound. Herein, we report this case with a brief review of the literature concerning pathogenesis, risk factors, and treatment approaches.

• Authors: Michael C Safioleas, Michael C Stamatakos, Ahmad I Diab, Panagiotis M Safioleas
• Journal: Saudi medical journal (Saudi Med J) Vol. 27 Issue 11 Pg. 1748-50 (Nov 2006) ISSN: 0379-5284 [Print] Saudi Arabia
• PMID: 17106556 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Anti-Infective Agents, Local
• Metronidazole
• Povidone-Iodine
• Oxygen
• Streptomycin

Topics

• Adolescent
• Anti-Bacterial Agents (administration & dosage, therapeutic use)
• Anti-Infective Agents, Local (administration & dosage, therapeutic use)
• Bandages
• Debridement
• Fournier Gangrene (diagnosis, drug therapy, surgery, therapy)
• Humans
• Male
• Metronidazole (administration & dosage, therapeutic use)
• Oxygen (administration & dosage)
• Perineum (injuries, surgery)
• Povidone-Iodine (administration & dosage, therapeutic use)
• Streptomycin (administration & dosage, therapeutic use)
• Time Factors
• Treatment Outcome
• Wound Healing