Immune thrombocytopenia after renal transplantation for IgA nephropathy.

Immune thrombocytopenic purpura associated with renal disease is usually therapy-related, occurring after administration of intravenous immunoglobulin therapy or anti-D. Secondary cases occurring after renal transplantation are extremely rare. We present the second reported case of immune thrombocytopenic purpura occurring after renal transplantation for IgA nephropathy. Primary IgA nephropathy is the most common form of primary glomerulonephritis and although the pathogenesis of the disease remains incompletely understood, recent evidence suggests that the basic abnormality lies within the IgA immune system rather than in the kidney. We postulate a novel mechanism for thrombocytopenia occurring in such cases.
AuthorsDipti Talaulikar, Michael Falk, Girish Talaulikar, Michael Pidcock
JournalActa haematologica (Acta Haematol) Vol. 117 Issue 2 Pg. 65-7 ( 2007) ISSN: 1421-9662 [Electronic] Switzerland
PMID17106188 (Publication Type: Case Reports, Journal Article)
Copyright2007 S. Karger AG, Basel
Chemical References
  • Immunoglobulin A
  • Adult
  • Blood Platelets (physiology)
  • Glomerulonephritis, IGA (surgery)
  • Humans
  • Immunoglobulin A (metabolism)
  • Kidney Transplantation (adverse effects)
  • Male
  • Purpura, Thrombocytopenic, Idiopathic (etiology)

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