T-cell-rich B-cell lymphoma of the spleen presenting with severe hypersplenism.

Abstract

We report a 19-year-old woman who was presented with B-symptoms, massive splenomegaly, hepatomegaly and hypersplenism. She underwent diagnostic/therapeutic splenectomy. Microscopically, the spleen showed a vaguely micronodular and diffuse proliferation of lymphoid cells in the white pulp that also involved the red pulp. On immunohistochemical staining, this proliferation consisted predominantly of CD3(+), CD7(+) small T cells with the presence of a minor population of CD15(-),CD30(-), CD20(+) large atypical B cells. A liver biopsy also showed a similar morphology to that seen in the spleen. After splenectomy, only the pancytopenia improved. A combined immunochemotherapy regimen (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone) was utilized, which resulted in a complete remission.

• Authors: G Dincol, M Agan, O Dogan, R Diz-Kucukkaya, B Uslu
• Journal: Clinical and laboratory haematology (Clin Lab Haematol) Vol. 28 Issue 6 Pg. 419-22 (Dec 2006) ISSN: 0141-9854 [Print] England
• PMID: 17105497 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Monoclonal
• Antibodies, Monoclonal, Murine-Derived
• Rituximab
• Vincristine
• Doxorubicin
• Cyclophosphamide
• Prednisone

Topics

• Adult
• Antibodies, Monoclonal (administration & dosage)
• Antibodies, Monoclonal, Murine-Derived
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Cyclophosphamide (administration & dosage)
• Doxorubicin (administration & dosage)
• Female
• Hepatomegaly (etiology)
• Histocytochemistry
• Humans
• Hypersplenism (etiology)
• Lymphoma, B-Cell (complications, diagnosis, drug therapy, pathology)
• Pancytopenia (etiology, therapy)
• Prednisone (administration & dosage)
• Rituximab
• Splenic Neoplasms (complications, drug therapy, pathology)
• T-Lymphocytes (pathology)
• Vincristine (administration & dosage)