The serotonin 5-HT1D receptor gene and attention-deficit hyperactivity disorder in Chinese Han subjects.

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a heritable disease. Serotonin is one of the neurotransmitters involved in the etiology of ADHD. Serotonin-1D receptors are autoreceptors which can regulate the release of serotonin in brain, so the HTR1D gene may be predisposing. The current study genotyped two variants of HTR1D gene in 272 ADHD trios of Chinese ethnicity, that is 1350T > C in the coding region and 1236A > G in 3'-UTR by the use of transmission disequilibrium test (TDT). The A allele of the 1236A > G polymorphism exhibited both a trend toward preferential transmission to ADHD probands (chi2 = 3.815, P = 0.051) and a significant preferential transmission to probands of ADHDC (chi2 = 4.198, P = 0.040). Additional polymorphisms in this gene need to be studied further.

• Authors: Jun Li, Xia Zhang, Yufeng Wang, Rulun Zhou, Haobo Zhang, Li Yang, Bing Wang, Stephen V Faraone
• Journal: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics (Am J Med Genet B Neuropsychiatr Genet) Vol. 141B Issue 8 Pg. 874-6 (Dec 05 2006) ISSN: 1552-4841 [Print] United States
• PMID: 17099886 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: (c) 2006 Wiley-Liss, Inc.

Chemical References

• Receptor, Serotonin, 5-HT1D

Topics

• Asian People (genetics)
• Attention Deficit Disorder with Hyperactivity (genetics)
• Genetic Predisposition to Disease
• Genotype
• Humans
• Inheritance Patterns (genetics)
• Polymorphism, Genetic
• Receptor, Serotonin, 5-HT1D (genetics)