Amuchina 10% solution, safe antiseptic for preventing infections of exit-site of Tenckhoff catheters, in the pediatric population of a dialysis program.

Abstract

Although, decreasing in incidence with the disconnection systems, the first complication is still peritonitis in patients with chronic renal failure and the second is infection of Tenckhoff catheter exit-site. All efforts made to diminish the frequency of exit-site infection lower the possibility of peritonitis. The pediatric population is well-known to have a major risk of infectious complications, and making easy and safe the care of the exit-site will prevent the peritonitis that follows. The aim of the study was to evaluate the efficacy of the Amuchina 10% solution vs. pH neutral soap in children with chronic renal failure, on preventing exit-site infection. There were 60 patients who were assigned randomly to one of two groups. One group used Amuchina 10% solution for the daily cleaning of the exit-site, and the other used pH neutral soap, with 14 months of follow-up. Before the study they have to be free of infection for at least 30 days. All were taught by the same nurse how to clean their exit-site. Groups were almost identical in years, sex, and time on dialysis. We had nine infections in the soap group and none in the Amuchina 10% solution group, with an OR: 17 (p = 0.004). From these nine infections, the bacteria isolated were: 4 (13%) were caused by Pseudomona aeruginosa, 1 (3.3%) by Staphylococcus aureus, coagulase-positive staphylococci in 2 (6.6%) and Serratia marcensens in 1 (3.3%). In conclusion, Amuchina 10% solution is effective in preventing infection on the exit-site, without any secondary topical reaction.

• Authors: L Mendoza-Guevara, F Castro-Vazquez, A Aguilar-Kitsu, A Morales-Nava, F Rodriguez-Leyva, J L Sanchez-Barbosa
• Journal: Contributions to nephrology (Contrib Nephrol) Vol. 154 Pg. 139-144 ( 2007) ISSN: 1662-2782 [Electronic] Switzerland
• PMID: 17099309 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Amuchina
• Anti-Infective Agents, Local
• Soaps
• Sodium Chloride
• Hypochlorous Acid

Topics

• Adolescent
• Anti-Infective Agents, Local (therapeutic use)
• Catheters, Indwelling (microbiology)
• Child
• Equipment Contamination (prevention & control)
• Female
• Follow-Up Studies
• Humans
• Hypochlorous Acid (therapeutic use)
• Incidence
• Infection Control (methods, statistics & numerical data)
• Kidney Failure, Chronic (therapy)
• Male
• Mexico (epidemiology)
• Peritoneal Dialysis (adverse effects, methods, statistics & numerical data)
• Peritonitis (epidemiology, prevention & control)
• Pseudomonas Infections (epidemiology, prevention & control)
• Serratia Infections (epidemiology, prevention & control)
• Skin Care (methods)
• Soaps
• Sodium Chloride (therapeutic use)
• Staphylococcal Infections (epidemiology, prevention & control)