Kleine-Levin syndrome in a 14-year-old girl: CSF hypocretin-1 measurements.

Abstract

CSF hypocretin-1 measurements were performed during a period of hypersomnia and during an asymptomatic interval in a 14-year-old girl affected with severe Kleine-Levin syndrome. A twofold decrease in hypocretin-1 was evidenced during the period of hypersomnia in comparison with the asymptomatic interval. Together with previous data, this result is in favour of recurrent dysfunction at the hypothalamic level in Kleine-Levin syndrome.

• Authors: Claudio Podestá, Mónica Ferreras, Marcela Mozzi, Claudio Bassetti, Yves Dauvilliers, Michel Billiard
• Journal: Sleep medicine (Sleep Med) Vol. 7 Issue 8 Pg. 649-51 (Dec 2006) ISSN: 1389-9457 [Print] Netherlands
• PMID: 17098473 (Publication Type: Case Reports, Journal Article)

Chemical References

• HCRT protein, human
• Intracellular Signaling Peptides and Proteins
• Neuropeptides
• Orexins

Topics

• Adolescent
• Female
• Humans
• Hypothalamus (physiopathology)
• Intracellular Signaling Peptides and Proteins (cerebrospinal fluid)
• Kleine-Levin Syndrome (cerebrospinal fluid)
• Neuropeptides (cerebrospinal fluid)
• Orexins