Abstract |
Three newborn infants who developed hyperbilirubinemia due to blood group incompatibility were treated with high-dose gammaglobulin. Hyperbilirubinemia was caused by Rhesus (Rh) incompatibility (anti-E + anti-c) in Infant 1 and ABO incompatibility (anti-B) in Infants 2 and 3. Hyperbilirubinemia was refractory to conventional phototherapy but responded well to intravenous gammaglobulin (IVGG) at a dose of 1 g/kg in all infants. No adverse effects were observed. These findings suggest that high-dose IVGG may be useful in the treatment of hyperbilirubinemia due to isoimmune haemolytic disease resistant to phototherapy.
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Authors | K Sato, T Hara, T Kondo, H Iwao, S Honda, K Ueda |
Journal | Acta paediatrica Scandinavica
(Acta Paediatr Scand)
Vol. 80
Issue 2
Pg. 163-6
(Feb 1991)
ISSN: 0001-656X [Print] Sweden |
PMID | 1709770
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Drug Combinations
- Immunoglobulins, Intravenous
- gamma-Globulins
- Fibrinolysin
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Topics |
- Drug Combinations
- Erythroblastosis, Fetal
(therapy)
- Female
- Fibrinolysin
(administration & dosage)
- Humans
- Immunization, Passive
- Immunoglobulins, Intravenous
- Infant, Newborn
- Male
- gamma-Globulins
(administration & dosage)
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