Abstract | BACKGROUND: AIMS: To evaluate whether the symptomatic effect of budesonide is linked to increased uptake of bile acids. METHODS: RESULTS: The median (75) SeHCAT retention increased from 18% to 35% (P < 0.001, n = 25) approaching the values of healthy controls (38%). The 7alpha-hydroxy-4-cholesten-3-one values decreased significantly among those with initially high synthesis (from 36 to 23 ng/mL, P = 0.04, n = 9); however, for the whole group the values were not altered (19 ng/mL vs. 13 ng/mL, P = 0.23, N.S., n = 19). CONCLUSION:
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Authors | A Bajor, A Kilander, C Gälman, M Rudling, K-A Ung |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 24
Issue 11-12
Pg. 1643-9
(Dec 2006)
ISSN: 0269-2813 [Print] England |
PMID | 17094773
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Bile Acids and Salts
- Budesonide
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Topics |
- Adult
- Aged
- Anti-Inflammatory Agents
(adverse effects)
- Bile Acids and Salts
(metabolism)
- Budesonide
(adverse effects)
- Colitis, Collagenous
(drug therapy)
- Female
- Humans
- Intestinal Absorption
- Male
- Middle Aged
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