[Protective effects of Xuebijing injection on kidney in rats with sepsis].

Abstract

OBJECTIVE:

To investigate the protective effects of the integrated traditional Chinese and Western medicine Xuebijing injection on the kidney in rats with sepsis.

METHODS:

Sepsis model was reproduced in rats with cecal ligation and puncture (CLP). Eighty healthy Wistar rats were randomly divided into four groups: control group, sham-operation group, CLP model group, and Xuebijing group. The two latter groups were divided into four groups of 2, 8, 24, 48-hour subgroups with 8 rats in each subgroup. Serum levels of creatinine (Cr), blood urea nitrogen (BUN), Na(+), K(+) were measured. beta (2)-microglobulin (beta (2)-MG) was determined by radioimmunoassay, urine level of Cr, Na(+), interleukin-6 (IL-6) levels in renal tissue, and fractional excretion of sodium (FENa) were determined by enzyme linked immunoadsorbent assay (ELISA). Light microscopy was used to assess the pathological changes in kidney.

RESULTS:

Compared with CLP model group,the level of beta (2)-MG was significantly decreased at 2 hours in Xuebijing group (P<0.01). Similarly, serum BUN content, renal IL-6 level were lowered at 8 hours, and serum contents of BUN as well as Cr were also decreased in Xuebijing group than those in model group at 48 hours after CLP (P<0.05 or P<0.01).

CONCLUSION:

Xuebijing injection possesses the protective effects on the kidney in rats with sepsis, which may be related with the synthesis and release of IL-6.

• Authors: Xue-qi Zhu, Lei Wang, Qing-quan Liu, Yong-ming Yao
• Journal: Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue (Zhongguo Wei Zhong Bing Ji Jiu Yi Xue) Vol. 18 Issue 11 Pg. 680-3 (Nov 2006) ISSN: 1003-0603 [Print] China
• PMID: 17092422 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drugs, Chinese Herbal
• Interleukin-6
• Xuebijing

Topics

• Animals
• Disease Models, Animal
• Drugs, Chinese Herbal (therapeutic use)
• Interleukin-6 (metabolism)
• Kidney (drug effects, metabolism, pathology)
• Male
• Random Allocation
• Rats
• Rats, Wistar
• Sepsis (drug therapy, pathology)