Abstract | OBJECTIVE: To investigate the curative effect and mechanism of beta-elemene interventional treatment on VX2 carcinoma transplanted on kidney in rabbits. METHODS: The rabbits were all transplanted with VX2 carcinoma on kidney. Fifty-five rabbits were randomly divided into 11 groups. Rabbits in these groups were administered interventional treatment of normal saline, iodinated oil, mitomycin, 5-fluorouracil, beta-elemene, cisplatin, carboplatin, adriamycin, thiotepa, cyclophopsphamide, and vincristine, respectively. After corresponding intervention, the tumor volume in each group was measured by ultrasonography and spiral computed tomography, and the tumor growth rate (TGR) was calculated. Nenal and hepatic functions of the rabbits in each group were compared 1 day, 7 and 14 days after the interventional treatment. Morphologic change of the tumor was observed by a light microscopy and a transmission electron microscopy 14 days after interventional treatment. The expressions of Bax and Bcl-2 were measured by immunohistochemical straining. RESULTS: CONCLUSION: Intervention treatment of beta-elemene has significant effect on VX2 kidney transplanted carcinoma and little side effect on the kidney function. Its mechanism is related to enhancing the apoptosis of tumor cells, and Bax gene participates in this action.
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Authors | Jun-Jun She, Zi-Ming Wang, Xiang-Ming Che, Cheng-En Pan |
Journal | Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
(Zhong Xi Yi Jie He Xue Bao)
Vol. 4
Issue 6
Pg. 611-4
(Nov 2006)
ISSN: 1672-1977 [Print] China |
PMID | 17090378
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Proto-Oncogene Proteins c-bcl-2
- Sesquiterpenes
- bcl-2-Associated X Protein
- beta-elemene
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Topics |
- Animals
- Antineoplastic Agents, Phytogenic
(administration & dosage)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Chemoembolization, Therapeutic
- Female
- Immunohistochemistry
- Injections, Intra-Arterial
- Kidney
(metabolism, pathology, ultrastructure)
- Kidney Neoplasms
(metabolism, pathology, therapy)
- Male
- Microscopy, Electron
- Neoplasm Transplantation
- Phytotherapy
- Proto-Oncogene Proteins c-bcl-2
(metabolism)
- Rabbits
- Random Allocation
- Sesquiterpenes
(administration & dosage)
- bcl-2-Associated X Protein
(metabolism)
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