Pregabalin (Lyrica) in the treatment of essential tremor.

Abstract

We report on 2 essential tremor patients who experienced marked improvement in upper extremity tremor with the use of pregabalin (Lyrica, PGB). On PGB 200 mg/day, tremor amplitude was reduced by at least 40% in the worst affected hand in both patients as measured by accelerometry. Both patients also reported moderate reduction in tremor on the Clinical Global Impression Scale, and Fahn-Tolosa-Marin Part I scores were markedly improved.

• Authors: Theresa A Zesiewicz, Christopher L Ward, Robert A Hauser, Jessica A Pease Campbell, Kelly L Sullivan
• Journal: Movement disorders : official journal of the Movement Disorder Society (Mov Disord) Vol. 22 Issue 1 Pg. 139-41 (Jan 2007) ISSN: 0885-3185 [Print] United States
• PMID: 17089400 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright 2006 Movement Disorder Society.

Chemical References

• Anticonvulsants
• Pregabalin
• gamma-Aminobutyric Acid

Topics

• Aged
• Anticonvulsants (therapeutic use)
• Dose-Response Relationship, Drug
• Essential Tremor (drug therapy, physiopathology)
• Humans
• Male
• Middle Aged
• Pregabalin
• Psychomotor Performance (drug effects)
• gamma-Aminobutyric Acid (analogs & derivatives, therapeutic use)