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VAB-6 chemotherapy causes spurious elevation of alpha-fetoprotein associated with liver dysfunctions.

Abstract
In order to elucidate the mechanism of elevation of alpha-fetoprotein (AFP) which we often observed during VAB-6 chemotherapy, we analyzed sequential changes of AFP, liver enzymes and bilirubin in 10 patients with evaluable disseminated testicular cancer who were treated with VAB-6 chemotherapy. None of the patients had previous liver disease or hepatic involvement. During the early phase of each course of chemotherapy, AFP showed a temporary elevation associated with reversible increase in liver enzymes and bilirubin. These changes returned to normal before the next course of chemotherapy. In each patient, marked tumor regression occurred as a result of VAB-6 chemotherapy. Nine of the 10 patients remain free of disease after treatment. We conclude that during VAB-6 chemotherapy, a temporary elevation of AFP is common, associated with reversible liver dysfunctions, and that this spurious elevation of the tumor marker, most likely caused by a heavy dose of cisplatin, should not be interpreted as related treatment failure.
AuthorsS Hida, K Nishimura, Y Nishio, K Oishi, H Takeuchi, O Yoshida
JournalUrologia internationalis (Urol Int) Vol. 46 Issue 1 Pg. 1-5 ( 1991) ISSN: 0042-1138 [Print] Switzerland
PMID1708922 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Biomarkers, Tumor
  • alpha-Fetoproteins
  • Bleomycin
  • Dactinomycin
  • Vinblastine
  • Cyclophosphamide
  • L-Lactate Dehydrogenase
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Cisplatin
Topics
  • Adult
  • Alanine Transaminase (blood)
  • Antineoplastic Combined Chemotherapy Protocols (adverse effects)
  • Aspartate Aminotransferases (blood)
  • Biomarkers, Tumor
  • Bleomycin (administration & dosage)
  • Chemical and Drug Induced Liver Injury
  • Cisplatin (administration & dosage)
  • Cyclophosphamide (administration & dosage)
  • Dactinomycin (administration & dosage)
  • Humans
  • L-Lactate Dehydrogenase (blood)
  • Liver Diseases (blood)
  • Male
  • Testicular Neoplasms (blood, drug therapy)
  • Vinblastine (administration & dosage)
  • alpha-Fetoproteins (metabolism)

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