[Serum macroamylase in a subject with non-Hodgkin's lymphoma].

Macroamylasemia (MA) is a rare condition characterized by an active macromolecular complex formed by normal amylase with abnormal proteins; to our knowledge, it has not been previously described in Mexico. The size of the macromolecular complex precludes its renal excretion; thus MA is characterized by high levels of amylase in serum with normal amylasuria. We report a 53-year-old male with abdominal pain and hyperamylasemia who was erroneously diagnosed as pancreatitis. Amylase in urine was normal and a protein electrophoresis demonstrated hyperglobulinemia. Several months after the initial work-up, the diagnosis of non-Hodgkin's lymphoma was established. Serum pancreatic amylase was again found elevated with normal urinary amylase. Precipitation of amylase with polyethylene-glycol was of 81% (normal: less than 70%). This established the diagnosis of MA associated to non-Hodgkin's lymphoma. After chemotherapy, the abnormal macroamylasemia and hyperglobulinemia disappeared.
AuthorsJ Ramón Enríquez, E Galván, L Uscanga, G Robles Díaz
JournalRevista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición (Rev Invest Clin) 1990 Oct-Dec Vol. 42 Issue 4 Pg. 285-9 ISSN: 0034-8376 [Print] MEXICO
Vernacular TitleMacroamilasemia en un sujeto con linfoma no-Hodgkin.
PMID1708911 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Neoplasm Proteins
  • Polyethylene Glycols
  • Amylases
  • Alcoholism (complications)
  • Amylases (blood)
  • Chemical Precipitation
  • Diagnostic Errors
  • Humans
  • Lymphoma, Non-Hodgkin (blood, diagnosis)
  • Male
  • Middle Aged
  • Neoplasm Proteins (blood)
  • Pancreatitis (diagnosis)
  • Polyethylene Glycols

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