[Case of severe eosinophilic pneumonia, induced by several antibiotics, requiring mechanical ventilation].

Abstract

We report a case of severe eosinophilic pneumonia induced by several antibiotics, requiring mechanical ventilation. A 44-year-old man had been admitted previously to a different hospital because of a high fever and dry cough continuing for a week. Although bacterial pneumonia was diagnosed and he had been treated with several antibiotics, his respiratory state worsened gradually and he was refered to our hospital with severe hypoxia. He needed mechanical ventilation on the fifth hospital day. TBLB identified eosinophilic pneumonia. Although we discontinued all antibiotics and started steroid therapy, he became feverish and his leukocyte count, which was neutrophil dominant, elevated again. We suspected bacterial pneumonia and administered antibiotics that he had never received before. However we had to discontinue these antibiotics soon because of a further inflammatory response. His condition then improved gradually and he was weaned from mechanical ventilation. It is rare for drug-induced eosinophilic pneumonia to become so severe that mechanical ventilation is necessary. We thought that an allergic reaction may have been induced by the series of several antibiotics, inducing severe pneumonia.

• Authors: Takehiro Nakamura, Yukiko Kawanami, Mika Yoshimoto, Hirofumi Kaneko, Satoshi Ominami, Chiharu Yoshii, Masamitsu Kido
• Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society (Nihon Kokyuki Gakkai Zasshi) Vol. 44 Issue 10 Pg. 695-700 (Oct 2006) ISSN: 1343-3490 [Print] Japan
• PMID: 17087334 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Anti-Bacterial Agents

Topics

• Adult
• Anti-Bacterial Agents (adverse effects)
• Drug Hypersensitivity (etiology)
• Humans
• Lymphocyte Activation
• Male
• Pulmonary Eosinophilia (chemically induced, diagnosis, therapy)
• Respiration, Artificial
• Severity of Illness Index