[Effects of jianwei yuyang granule on inflammatory reaction and NF-kappaB expression in rat gastric mucosa of ulcer healing and recurrence].

Abstract

OBJECTIVE:

To observe the effects of Jianwei Yuyang granule (JWYY) on inflammatory reaction and NF-kappaB expression in rat gastric mucosa of ulcer healing and recurrence.

METHOD:

Gastric ulcer was induced in rat by acetic acid according Okeba's method with some modification and the recurrence model was induced by IL-1beta. Pathohistology of ulcer healing and recurrence was observed. Density of inflammatory cell infiltrating regenerative mucosa, NF-kappaB protein and mRNA expression were measured.

RESULT:

JWYY had effects on improving the quality of ulcer healing, reducing the rate of ulcer recurrence, decreasing the density of inflammatory cell infiltrating regenerative mucosa and suppressing the activation and expression quantity of NF-kappaB protein and mRNA.

CONCLUSION:

JWYY may promote the ulcer healing and prevent the recurrence of the gastric ulcer by suppressing the activation of NF-kappaB and the following inflammatory reaction.

• Authors: Jiang-Hong Ling, Ye-Qiang Chen, Jia-Bang Li, Yu-Zheng Pan, Yang Cao, Ding-Zhu Shen
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 31 Issue 17 Pg. 1454-7 (Sep 2006) ISSN: 1001-5302 [Print] China
• PMID: 17087090 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drug Combinations
• Drugs, Chinese Herbal
• NF-kappa B
• RNA, Messenger
• Acetic Acid

Topics

• Acetic Acid
• Animals
• Drug Combinations
• Drugs, Chinese Herbal (isolation & purification, pharmacology)
• Female
• Gastric Mucosa (metabolism, pathology)
• Male
• NF-kappa B (biosynthesis, genetics)
• Plants, Medicinal (chemistry)
• RNA, Messenger (biosynthesis)
• Rats
• Rats, Sprague-Dawley
• Recurrence
• Stomach Ulcer (chemically induced, metabolism, pathology)