HLA-DRB1*04 alleles in Japanese rheumatoid arthritis patients with AA amyloidosis.

Abstract

OBJECTIVE:

To compare the HLA-DRB1 shared epitope (SE) alleles in Japanese patients with rheumatoid arthritis (RA) and amyloid A (AA) amyloidosis versus those without AA amyloidosis.

METHODS:

The HLA-DRB1 alleles were genotyped for 91 RA patients without AA amyloidosis, 33 RA patients with AA amyloidosis, and 63 control subjects. HLA-DRB1 typing was performed by polymerase chain reaction, sequence-specific oligonucleotide probe hybridization method.

RESULTS:

Although a significant difference was not observed, the frequency of SE genotype was higher in RA patients with AA amyloidosis than in those without AA amyloidosis. All SE-positive RA patients with AA amyloidosis had *04 alleles (*0401, *0405, *0410), and a significant association of the presence of a double dose of *04 SE alleles with AA amyloidosis (OR 4.0, 95% CI 1.91-13.99) was observed.

CONCLUSION:

Our data suggest that presence of double *04 SE is associated with a higher risk of developing AA amyloidosis in Japanese patients with RA.

• Authors: Kiyoshi Migita, Tadashi Nakamura, Yumi Maeda, Taichiro Miyashita, Tomoki Origuchi, Hiroshi Yatsuhashi, Minoru Nakamura, Hiromi Ishibashi, Katsumi Eguchi
• Journal: The Journal of rheumatology (J Rheumatol) Vol. 33 Issue 11 Pg. 2120-3 (Nov 2006) ISSN: 0315-162X [Print] Canada
• PMID: 17086601 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Epitopes
• HLA-DR Antigens
• HLA-DRB1 Chains
• Serum Amyloid A Protein

Topics

• Aged
• Amyloidosis (ethnology, etiology, genetics)
• Arthritis, Rheumatoid (complications, ethnology, genetics)
• Asian People
• Case-Control Studies
• Epitopes (genetics, immunology)
• Female
• Genetic Predisposition to Disease
• Genotype
• HLA-DR Antigens (genetics, immunology)
• HLA-DRB1 Chains
• Humans
• Japan
• Male
• Middle Aged
• Serum Amyloid A Protein (genetics)