| Abstract | INTRODUCTION: Lamotrigine is an anti-epileptic drug considered as a first-line therapy in idiopathic generalised epilepsy. Lamotrigine is well-tolerated and secondary aggravation of epileptic syndromes has rarely been reported. CASE REPORT: We report the case of a 19 year-old man with juvenile myoclonic epilepsy in whom lamotrigine lead to the exacerbation of generalised tonico-clonic seizures, reversible when lamotrigine was stopped and substituted by valproic acid. CONCLUSION: Lamotrogine may induce exacerbation of generalised tonico-clonic seizures and myoclonic jerks in juvenile myoclonic epilepsy. |
| Authors | Y Maiga, B Nogues, B Guillon
(Affiliation: Clinique Neurologique, Hôpital Laënnec, Nantes.)
|
| Journal | Revue neurologique
(Rev Neurol (Paris))
Vol. 162
Issue 11
Pg. 1125-7
(Nov 2006)
ISSN: 0035-3787 France |
| Vernacular Title | Accentuation des crises tonico-cloniques sous lamotrigine dans l'épilepsie myoclonique juvénile. |
| PMID | 17086150
(Publication Type: Case Reports, English Abstract, Journal Article)
|
| Chemical References |
- Anticonvulsants
- Triazines
- lamotrigine
- Valproic Acid
|
| Topics |
- Adult
- Anticonvulsants
(adverse effects, therapeutic use)
- Electroencephalography
- Epilepsy, Tonic-Clonic
(chemically induced, complications)
- Humans
- Male
- Myoclonic Epilepsy, Juvenile
(complications, drug therapy)
- Triazines
(adverse effects, therapeutic use)
- Valproic Acid
(therapeutic use)
|
