hOGG1 Ser326Cys polymorphism and risk of hepatocellular carcinoma among Japanese.

Abstract

BACKGROUND:

The Ser326Cys polymorphism in human oxoguanine glycosylase 1 (hOGG1), which is involved in the repair of 8-hydroxy-2-deoxyguanine in oxidatively damaged DNA, has been associated with susceptibility to certain cancers, but has not been examined in causation of hepatocellular carcinoma (HCC).

METHODS:

We conducted a case-control study to investigate whether this polymorphism was related to HCC risk with any interaction with alcohol consumption and cigarette smoking. Genotyping was performed by a polymerase chain reaction with confronting two-pair primers among 209 newly diagnosed HCC cases, 275 hospital controls, and 381 patients with chronic liver disease (CLD) without HCC.

RESULTS:

Overall, the hOGG1 genotype was not significantly associated with HCC; adjusted odds ratios (and 95% confidence intervals) for the Ser/Cys and Cys/Cys genotypes compared with the Ser/Ser genotype were 0.79 (0.35-1.79) and 0.48 (0.18-1.27) against hospital controls, and 1.51 (0.96-3.37) and 0.86 (0.50-1.47) against CLD patients. We could not detect any significant gene-alcohol interaction (p = 0.95 or 0.16) or gene-smoking interaction (p = 0.70 or 0.69).

CONCLUSIONS:

These results suggest that the hOGG1 Ser326Cys polymorphism may not play a major role as an independent factor in hepatocarcinogenesis.

• Authors: Tatsuhiko Sakamoto, Yasuki Higaki, Megumi Hara, Masayoshi Ichiba, Mikako Horita, Toshihiko Mizuta, Yuichiro Eguchi, Tsutomu Yasutake, Iwata Ozaki, Kyosuke Yamamoto, Shingo Onohara, Seiji Kawazoe, Hirohisa Shigematsu, Shunzo Koizumi, Keitaro Tanaka
• Journal: Journal of epidemiology (J Epidemiol) Vol. 16 Issue 6 Pg. 233-9 (Nov 2006) ISSN: 0917-5040 [Print] Japan
• PMID: 17085873 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Serine
• DNA Glycosylases
• oxoguanine glycosylase 1, human

Topics

• Adult
• Aged
• Amino Acid Substitution
• Carcinoma, Hepatocellular (genetics)
• Case-Control Studies
• DNA Glycosylases (genetics)
• Female
• Genetic Predisposition to Disease
• Humans
• Japan
• Liver Neoplasms (genetics)
• Male
• Middle Aged
• Polymorphism, Genetic
• Serine (genetics)