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103Pd radioactive stent inhibits biliary duct restenosis and reduces smooth muscle actin expression during duct healing in dogs.

AbstractBACKGROUND:
This study was designed to assess the expression of smooth muscle actin (SMA) in the healing process after implanting a (103)Pd radioactive stent in the biliary duct, and to discuss the function and significance of this stent in preventing biliary stricture formation.
METHODS:
A model of biliary injury in dogs was made and then a (103)Pd radioactive stent was positioned in the biliary duct. The expression and distribution of SMA were assessed in the anastomotic tissue 30 days after implantation of the stent.
RESULTS:
SMA expression was less in the (103)Pd stent group than in the ordinary stent group. The (103)Pd stent inhibited scar contracture and anastomotic stenosis.
CONCLUSION:
The (103)Pd stent can reduce the expression of SMA in the healing process and inhibit scar contracture and anastomotic stenosis in the dog biliary duct.
AuthorsGui-Jin He, Qin-Yi Gao, Shu-He Xu, Hong Gao, Tao Jiang, Xian-Wei Dai, Kai Ma
JournalHepatobiliary & pancreatic diseases international : HBPD INT (Hepatobiliary Pancreat Dis Int) Vol. 5 Issue 4 Pg. 595-8 (Nov 2006) ISSN: 1499-3872 [Print] Singapore
PMID17085349 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Actins
  • Radioisotopes
  • Palladium
Topics
  • Actins (metabolism)
  • Animals
  • Bile Ducts, Extrahepatic (metabolism, pathology, surgery)
  • Constriction, Pathologic (pathology, prevention & control)
  • Dogs
  • Male
  • Muscle, Smooth (metabolism)
  • Palladium
  • Radioisotopes
  • Stents

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