Abstract | BACKGROUND: This study was designed to assess the expression of smooth muscle actin (SMA) in the healing process after implanting a (103)Pd radioactive stent in the biliary duct, and to discuss the function and significance of this stent in preventing biliary stricture formation. METHODS: A model of biliary injury in dogs was made and then a (103)Pd radioactive stent was positioned in the biliary duct. The expression and distribution of SMA were assessed in the anastomotic tissue 30 days after implantation of the stent. RESULTS: CONCLUSION: The (103)Pd stent can reduce the expression of SMA in the healing process and inhibit scar contracture and anastomotic stenosis in the dog biliary duct.
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Authors | Gui-Jin He, Qin-Yi Gao, Shu-He Xu, Hong Gao, Tao Jiang, Xian-Wei Dai, Kai Ma |
Journal | Hepatobiliary & pancreatic diseases international : HBPD INT
(Hepatobiliary Pancreat Dis Int)
Vol. 5
Issue 4
Pg. 595-8
(Nov 2006)
ISSN: 1499-3872 [Print] Singapore |
PMID | 17085349
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Actins
- Radioisotopes
- Palladium
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Topics |
- Actins
(metabolism)
- Animals
- Bile Ducts, Extrahepatic
(metabolism, pathology, surgery)
- Constriction, Pathologic
(pathology, prevention & control)
- Dogs
- Male
- Muscle, Smooth
(metabolism)
- Palladium
- Radioisotopes
- Stents
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